Histomorphometric analysis of liver biopsies of treated patients with Gaucher disease type 1
Visualizar/abrir
Data
2021Autor
Tipo
Assunto
Abstract
Gaucher disease (GD) is an autosomal recessive lysosomal disorder caused by a disturbance in the metabolism of glucocerebroside in the macrophages. Most of its manifestations – hepatosplenomegaly, anemia, thrombocytopenia, and bone pain – are amenable to a macrophage-target therapy such as enzyme replacement. However, there is increasing evidence that abnormalities of the liver persist despite the specific GD treatment. In this work, we adapted histomorphometry techniques to the study of hepato ...
Gaucher disease (GD) is an autosomal recessive lysosomal disorder caused by a disturbance in the metabolism of glucocerebroside in the macrophages. Most of its manifestations – hepatosplenomegaly, anemia, thrombocytopenia, and bone pain – are amenable to a macrophage-target therapy such as enzyme replacement. However, there is increasing evidence that abnormalities of the liver persist despite the specific GD treatment. In this work, we adapted histomorphometry techniques to the study of hepatocytes in GD using liver tissue of treated patients, developing the first morphometrical method for canalicular quantification in immunohistochemistry-stained liver biopsies, and exploring histomorphometric characteristics of GD. This is the first histomorphometric technique developed for canalicular analysis on histological liver biopsy samples. ...
Contido em
Autopsy and case reports. São Paulo, SP. Vol. 11 (2021), e2021306, 7 p.
Origem
Nacional
Coleções
-
Artigos de Periódicos (40836)Ciências Biológicas (3217)
-
Artigos de Periódicos (40836)Ciências da Saúde (10901)
Este item está licenciado na Creative Commons License
![](/themes/Mirage2Novo//images/lume/cc.png)