• In silico and in vivo pharmacological evaluation of iridoid compounds : geniposide and asperuloside profile study through molecular docking assay and in the Caenorhabditis elegans model 

  Uczay, Mariana; Santos, Péterson Alves; Pflüger, Pricila Fernandes; Von Poser, Gilsane Lino; Brea, José; Loza, María Isabel; Pereira, Patricia; Fontenla, José Angel (2025) [Artigo de periódico]

  Iridoids are compounds recognized for their neuroprotective properties and their potential application in the treatment of neurodegenerative diseases. Geniposide (GP) and asperuloside (ASP) are iridoids that have demonstrated ...
• Achyrocline satureioides : in silico and in vivo evaluation of the potential neuroprotective effect of the aqueous extract 

  Santos, Péterson Alves; Pflüger, Pricila Fernandes; Rott, Marilise Brittes; Gómez-Couso, Hipólito; Siqueira, Ionara Rodrigues; Pereira, Patricia; Fontenla, José Angel (2025) [Artigo de periódico]

  Ethnopharmacological relevance Achyrocline satureioides (Lam.) DC is traditionally used as an infusion in several South American countries to treat various health conditions, including those affecting the central nervous ...
• Peripheral leptin receptor gene network modulates the impact of childhood adversity on mental health disorders 

  Lima, Randriely Merscher Sobreira de; Barth, Bárbara; Arcego, Danusa Mar; Mendonça Filho, Euclides José de; Patel, Sachin; Wang, Zihan; Elgbeili, Guillaume; Pokhvisneva, Irina; Parent, Carine I.; Levitan, Robert D.; Kobor, Michael S.; Dalmaz, Carla; Silveira, Patrícia Pelufo (2025) [Artigo de periódico]

  Psychiatric disorders are highly prevalent and often co-morbid with metabolic syndrome. Exposure to adversity in early life is a risk factor for both metabolic and behavioral problems, modifying leptin metabolism and ...
• Microbial diversity and composition in the gut microbiome of patients during systemic inflammatory response syndrome : can we use gut bacteria as potential biomarkers to characterize sepsis? 

  Guerra, Rafaela Ramalho; Fernandes, Patrícia da Silva; Lovison, Otávio von Ameln; Forni, Giovanna de Ross; Oliveira, Gabriel Silva de; Viana, Luana Cristina; Pereira, Dariane Castro; Matos, William Latosinski; Moretti, Miriane Melo Silveira; Volpato, Fabiana Caroline Zempulski; Giordani, Luciana; Barth, Patricia Orlandi; Vieceli, Tarsila; Falci, Diego Rodrigues; Boniatti, Márcio Manozzo; Barth, Afonso Luis; Martins, Andreza Francisco (2025) [Artigo de periódico]

  Background: Critically ill patients, including those with systemic inflammatory response syndrome (SIRS) and sepsis, frequently exhibit gut microbiota disruption due to physiological stress and broad-spectrum antimicrobial ...
• Molecular epidemiology of a carbapenem-resistant Serratia marcescens outbreak during the COVID-19 pandemic 

  Rocha, Letícia Fernandes da; Rodrigues, Grazielle Motta; Oliveira, Gabriela Simões de; Echevarria, Aymê Duarte; Wink, Priscila Lamb; Volpato, Fabiana Caroline Zempulski; Berdichevski, Mayana Kieling Hernandez; Lutz, Larissa; Pereira, Dariane Castro; Barth, Afonso Luis; Martins, Andreza Francisco (2025) [Artigo de periódico]

  Introduction: Serratia marcescens is a significant causative agent of hospital-acquired infections (HAIs), particularly in intensive care units (ICUs). Carbapenem resistance represents a major concern in HAI management, ...
• Validation of the Brazilian version of the processes of change questionnaire in weight management in adults with overweight and obesity in Brazil 

  Carvalho, Quênia de; Ziani, Paola Rampelotto; Montezano, Bruno Braga; Goularte, Jeferson Ferraz; Rosa, Adriane Ribeiro (2025) [Artigo de periódico]

  In Brazil, 57.5% of men and 62.6% of women are considered overweight, highlighting obesity as a public health issue. Obesity increases the risk of various chronic diseases, and most people struggle to maintain weight loss ...
• CSF total tau as a proxy of synaptic degeneration 

  Katz, Carolina Soares; Zimmer, Eduardo Rigon; Pascoal, Tharick Ali (2025) [Artigo de periódico]

  Cerebrospinal fluid (CSF) total tau (t-tau) is considered a biomarker of neuronal degeneration alongside brain atrophy and fluid neurofilament light chain protein (NfL) in biomarker models of Alzheimer’s disease (AD). ...
• American Basil, Ocimum americanum, has neuroprotective properties in the aging process 

  Siqueira, Ionara Rodrigues; Vanzella, Cláudia; Lovatel, Gisele Agustini; Bertoldi, Karine; Spindler, Chirstian; Moysés, Felipe dos Santos; Vizuete, Adriana Fernanda Kuckartz; Von Poser, Gilsane Lino; Netto, Carlos Alexandre (2025) [Artigo de periódico]

  Background/Objectives: There is evidence concerning herbal medicines and plant-based compounds, including Lamiaceae species, as putative senolytic agents; however, there are only a few reports on Ocimum americanum properties ...
• The evolution of randomized clinical trial designs to assess therapeutics in Alzheimer disease 

  Aumont, Étienne; Therriault, Joseph; Kwan, Angela Tian Hui; Collar, Giovanna Carello; Arfaie, Saman; Hall, Brandon J.; Souza, João Pedro Ferrari; Woo, Marcel Seungsu; Macedo, Arthur C.; Tissot, Cecile; Trudel, Lydia; Rahmouni, Nesrine; Servaes, Stijn; Vitali, Paolo; Soucy, Jean-Paul; Pascoal, Tharick Ali; Zimmer, Eduardo Rigon; Gauthier, Serge G.; Rosa Neto, Pedro (2025) [Artigo de periódico]

  IMPORTANCE: The success of recent randomized clinical trials (RCTs) for Alzheimer disease (AD), particularly those focusing on anti-amyloid therapies, has been discussed at length. However, the evolution of RCT design ...
• Downregulation of miR-27a-3p modulates TGF-β signaling and dysregulates metabolism in glioblastoma 

  Weber, Augusto Ferreira; Scholl, Juliete Nathali; Dias, Camila kehl; Lima, Vinícius Pierdoná; De Bona, Tamires; Marschner, Renata; Sousa, Arieli Cruz de; Klamt, Fabio; Figueiró, Fabrício (2025) [Artigo de periódico]

  Several microRNAs (miRNAs) are key influencers of tumor microenvironment (TME) cell plasticity, regulating the progression of various tumor types such as glioblastoma (GBM). Differential expressions of miR-27a-3p and ...

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