A enzima 2-trans-enoil-ACP (COA) redutase de Mycobacterium tuberculosis : inibição por um novo composto e estudos espectroscópicos do seu mecanismo de resistência à hidrazida do ácido isonicotínico
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2009Autor
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Abstract
Tuberculosis (TB) is a neglected disease, which continue to be major cause of morbidity and mortality worldwide, killing together around 5 million people each year. Mycolic acids, the hallmark of mycobacteria, are high-molecular-weight α-alkyl, β-hydroxy fatty acids. Biochemical and genetic experimental data have shown that the product of the M. tuberculosis inhA structural gene (InhA) is the primary target of isoniazid mode of action, the most prescribed anti-tubercular agent. InhA was identif ...
Tuberculosis (TB) is a neglected disease, which continue to be major cause of morbidity and mortality worldwide, killing together around 5 million people each year. Mycolic acids, the hallmark of mycobacteria, are high-molecular-weight α-alkyl, β-hydroxy fatty acids. Biochemical and genetic experimental data have shown that the product of the M. tuberculosis inhA structural gene (InhA) is the primary target of isoniazid mode of action, the most prescribed anti-tubercular agent. InhA was identified as an NADH-dependent enoyl-ACP(CoA) reductase specific for long-chain enoyl thioesters and is a member of the Type II fatty acid biosynthesis system, which elongates acyl fatty acid precursors of mycolic acids. M. tuberculosis is a target for the development of anti-tubercular agents. Here we present a brief description of the mechanism of action of, and resistance to, isoniazid. In addition, data on inhibition of mycobacterial enoyl reductase by triclosan are presented. We also describe recent efforts to develop inhibitors of M. tuberculosis enoyl reductase enzyme activity. ...
Instituição
Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia do Estado do Rio Grande do Sul. Programa de Pós-Graduação em Biologia Celular e Molecular.
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Ciências Biológicas (3914)
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