Association of anxiety with intracortical inhibition and descending pain modulation in chronic myofascial pain syndrome
dc.contributor.author | Vidor, Liliane Pinto | pt_BR |
dc.contributor.author | Torres, Iraci Lucena da Silva | pt_BR |
dc.contributor.author | Medeiros, Liciane Fernandes | pt_BR |
dc.contributor.author | Sarria, Jairo Alberto Dussán | pt_BR |
dc.contributor.author | Dall'Agnol, Letizzia | pt_BR |
dc.contributor.author | Deitos, Alícia | pt_BR |
dc.contributor.author | Brietzke, Aline Patrícia | pt_BR |
dc.contributor.author | Laste, Gabriela | pt_BR |
dc.contributor.author | Rozisky, Joanna Ripoll | pt_BR |
dc.contributor.author | Fregni, Felipe | pt_BR |
dc.contributor.author | Caumo, Wolnei | pt_BR |
dc.date.accessioned | 2015-02-14T02:19:06Z | pt_BR |
dc.date.issued | 2014 | pt_BR |
dc.identifier.issn | 1471-2202 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/110151 | pt_BR |
dc.description.abstract | Background: This study aimed to answer three questions related to chronic myofascial pain syndrome (MPS): 1) Is the motor cortex excitability, as assessed by transcranial magnetic stimulation parameters (TMS), related to state-trait anxiety? 2) Does anxiety modulate corticospinal excitability changes after evoked pain by Quantitative Sensory Testing (QST)? 3) Does the state-trait anxiety predict the response to pain evoked by QST if simultaneously receiving a heterotopic stimulus [Conditional Pain Modulation (CPM)]? We included females with chronic MPS (n = 47) and healthy controls (n = 11), aged 19 to 65 years. Motor cortex excitability was assessed by TMS, and anxiety was assessed based on the State-Trait Anxiety Inventory. The disability related to pain (DRP) was assessed by the Profile of Chronic Pain scale for the Brazilian population (B:PCP:S), and the psychophysical pain measurements were measured by the QST and CPM. Results: In patients, trait-anxiety was positively correlated to intracortical facilitation (ICF) at baseline and after QST evoked pain (β = 0.05 and β = 0.04, respectively) and negatively correlated to the cortical silent period (CSP) (β = -1.17 and β = -1.23, respectively) (P <0.05 for all comparisons). After QST evoked pain, the DRP was positively correlated to ICF (β= 0.02) (P < 0.05). Pain scores during CPM were positively correlated with trait-anxiety when it was concurrently with high DRP (β = 0.39; P = 0.02). Controls’ cortical excitability remained unchanged after QST. Conclusions: These findings suggest that, in chronic MPS, the imbalance between excitatory and inhibitory descending systems of the corticospinal tract is associated with higher trait-anxiety concurrent with higher DRP. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | BMC neuroscience. London. Vol. 15 (19 mar. 2014), 42 [13] p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Ansiedade | pt_BR |
dc.subject | Transcranial magnetic stimulation | en |
dc.subject | Chronic pain | en |
dc.subject | Síndromes da dor miofascial | pt_BR |
dc.subject | Noninvasive brain stimulation | en |
dc.subject | Estimulação magnética transcraniana | pt_BR |
dc.subject | Neuromodulation | en |
dc.subject | Dor crônica | pt_BR |
dc.subject | Anxiety | en |
dc.subject | Myofascial pain syndrome | en |
dc.title | Association of anxiety with intracortical inhibition and descending pain modulation in chronic myofascial pain syndrome | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000915989 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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