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dc.contributor.authorBorges, Silvia Coelhopt_BR
dc.contributor.authorCheinquer, Hugopt_BR
dc.contributor.authorWolff, Fernando Herzpt_BR
dc.contributor.authorCheinquer, Nelsonpt_BR
dc.contributor.authorKrug, Lucianopt_BR
dc.contributor.authorProlla, Patrícia Ashtonpt_BR
dc.date.accessioned2014-04-30T01:52:04Zpt_BR
dc.date.issued2012pt_BR
dc.identifier.issn0004-2803pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/94854pt_BR
dc.description.abstractContext - Abnormal serum ferritin levels are found in approximately 20%-30% of the patients with chronic hepatitis C and are associated with a lower response rate to interferon therapy. Objective - To determine if the presence of HFE gene mutations had any effect on the sustained virological response rate to interferon based therapy in chronic hepatitis C patients with elevated serum ferritin. Methods - A total of 44 treatment naïve patients with histologically demonstrated chronic hepatitis C, all infected with hepatitis C virus genotype non-1 (38 genotype 3; 6 genotype 2) and serum ferritin above 500 ng/mL were treated with interferon (3 MU, 3 times a week) and ribavirin (1.000 mg, daily) for 24 weeks. Results - Sustained virological response was defined as negative qualitative HCV-RNA more than 24 weeks after the end of treatment. Serum HCV-RNA was measured by qualitative in house polymerase chain reaction with a limit of detection of 200 IU/mL. HFE gene mutation was detected using restriction-enzyme digestion with RsaI (C282Y mutation analysis) and BclI (H63D mutation analysis) in 16 (37%) patients, all heterozygous (11 H63D, 2 C282Y and 3 both). Sustained virological response was achieved in 0 of 16 patients with HFE gene mutations and 11 (41%) of 27 patients without HFE gene mutations (P = 0.002; exact Fisher test). Conclusion - Heterozigozity for H63D and/or C282Y HFE gene mutation predicts absence of sustained virological response to combination treatment with interferon and ribavirin in patients with chronic hepatitis C, non-1 genotype and serum ferritin levels above 500 ng/mL.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofArquivos de gastroenterologia = Archives of gastroenterology. São Paulo. Vol. 49, n. 1 (jan./mar. 2012), p. 9-13pt_BR
dc.rightsOpen Accessen
dc.subjectPolymorphysm, geneticen
dc.subjectPolimorfismo genéticopt_BR
dc.subjectHepatite C crônicapt_BR
dc.subjectHepatitis C, chronicen
dc.subjectFerritinaspt_BR
dc.subjectFerritinsen
dc.subjectInterferonsen
dc.subjectInterferonspt_BR
dc.titleEffect of hfe gene polymorphism on sustained virological response in patients with chronic hepatitis c and elevated serum ferritinpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000867357pt_BR
dc.type.originNacionalpt_BR


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