Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
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Date
2004Author
Type
Title alternative
Degradation and stabilization of diclofenac in polymeric nanocapsules
Subject
Abstract
The parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage at room temperature. In addition, a study of the degradation of diclofenac was carried out by exposing the formulations or mixtures (drug and adjuvants) to UVC wavelengths. The presence of Epikuron 170® in a concentration higher than 3.06 mg/mL stabilizes the drug, avoiding i ...
The parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage at room temperature. In addition, a study of the degradation of diclofenac was carried out by exposing the formulations or mixtures (drug and adjuvants) to UVC wavelengths. The presence of Epikuron 170® in a concentration higher than 3.06 mg/mL stabilizes the drug, avoiding its reduction or degradation. The degradation products were isolated, analyzed by gas chromatography-mass spectrometry, and identified as 2-(2’,6’- dichlorophenyl)aminobenzyl alcohol and N-(2’,6’-dichlorophenyl)anthranilylaldehyde. ...
In
Química nova. São Paulo. Vol. 27, n. 4 (2004), p. 555-560
Source
National
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