Improvement of genistein content in solid genistein/β-cyclodextrin complexes

Xavier, Clarissa Ruaro; Silva, Ana Paula Cappra; Schwingel, Liege Cassia; Borghetti, Greice Stefani; Koester, Leticia Scherer; Mayorga Borges, Paulo Eduardo; Teixeira, Helder Ferreira; Bassani, Valquiria Linck; Lula, Ivana; Sinisterra, Ruben Dario

dc.contributor.author	Xavier, Clarissa Ruaro	pt_BR
dc.contributor.author	Silva, Ana Paula Cappra	pt_BR
dc.contributor.author	Schwingel, Liege Cassia	pt_BR
dc.contributor.author	Borghetti, Greice Stefani	pt_BR
dc.contributor.author	Koester, Leticia Scherer	pt_BR
dc.contributor.author	Mayorga Borges, Paulo Eduardo	pt_BR
dc.contributor.author	Teixeira, Helder Ferreira	pt_BR
dc.contributor.author	Bassani, Valquiria Linck	pt_BR
dc.contributor.author	Lula, Ivana	pt_BR
dc.contributor.author	Sinisterra, Ruben Dario	pt_BR
dc.date.accessioned	2013-07-02T01:43:21Z	pt_BR
dc.date.issued	2010	pt_BR
dc.identifier.issn	0100-4042	pt_BR
dc.identifier.uri	http://hdl.handle.net/10183/72883	pt_BR
dc.description.abstract	Genistein: β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β-cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature.	en
dc.format.mimetype	application/pdf	pt_BR
dc.language.iso	eng	pt_BR
dc.relation.ispartof	Química nova. São Paulo. Vol. 33, n. 3 (2010), p. 587-590	pt_BR
dc.rights	Open Access	en
dc.subject	Genisteína	pt_BR
dc.subject	Genistein	en
dc.subject	Ciclodextrina	pt_BR
dc.subject	β-cyclodextrin	en
dc.subject	Isoflavonas : Grao de soja	pt_BR
dc.subject	Computer molecular mechanics	en
dc.subject	Complexação	pt_BR
dc.title	Improvement of genistein content in solid genistein/β-cyclodextrin complexes	pt_BR
dc.type	Artigo de periódico	pt_BR
dc.identifier.nrb	000752046	pt_BR
dc.type.origin	Nacional	pt_BR

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