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Improvement of genistein content in solid genistein/β-cyclodextrin complexes

dc.contributor.authorXavier, Clarissa Ruaropt_BR
dc.contributor.authorSilva, Ana Paula Capprapt_BR
dc.contributor.authorSchwingel, Liege Cassiapt_BR
dc.contributor.authorBorghetti, Greice Stefanipt_BR
dc.contributor.authorKoester, Leticia Schererpt_BR
dc.contributor.authorMayorga Borges, Paulo Eduardopt_BR
dc.contributor.authorTeixeira, Helder Ferreirapt_BR
dc.contributor.authorBassani, Valquiria Linckpt_BR
dc.contributor.authorLula, Ivanapt_BR
dc.contributor.authorSinisterra, Ruben Dariopt_BR
dc.date.accessioned2013-07-02T01:43:21Zpt_BR
dc.date.issued2010pt_BR
dc.identifier.issn0100-4042pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/72883pt_BR
dc.description.abstractGenistein: β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β-cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofQuímica nova. São Paulo. Vol. 33, n. 3 (2010), p. 587-590pt_BR
dc.rightsOpen Accessen
dc.subjectGenisteínapt_BR
dc.subjectGenisteinen
dc.subjectCiclodextrinapt_BR
dc.subjectβ-cyclodextrinen
dc.subjectIsoflavonas : Grao de sojapt_BR
dc.subjectComputer molecular mechanicsen
dc.subjectComplexaçãopt_BR
dc.titleImprovement of genistein content in solid genistein/β-cyclodextrin complexespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000752046pt_BR
dc.type.originNacionalpt_BR


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