Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graft
dc.contributor.author | Puricelli, Edela | pt_BR |
dc.contributor.author | Corsetti, Adriana | pt_BR |
dc.contributor.author | Ponzoni, Deise | pt_BR |
dc.contributor.author | Martins, Gustavo Lisboa | pt_BR |
dc.contributor.author | Leite, Mauro Gomes Trein | pt_BR |
dc.contributor.author | Santos, Luis Alberto dos | pt_BR |
dc.date.accessioned | 2011-08-03T06:00:51Z | pt_BR |
dc.date.issued | 2010 | pt_BR |
dc.identifier.issn | 1746-160X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/30488 | pt_BR |
dc.description.abstract | Background: In this study, the biocompatibility, stability and osteotransductivity of a new cement based on alphatricalcium phosphate (alpha-TCP) were investigated in a bone repair model using a rat model. Methods: The potential of alpha-TCP on bone repair was compared to autogenous bone grafting, and unfilled cavities were used as negative control. Surgical cavities were prepared and designated as test (T), implanted with alpha-TCP blocks; negative control (C - ), unfilled; and positive control (C + ), implanted with autogenous bone graft. Results were analyzed on postoperative days three, seven, 14, 21 and 60. Results: The histological analyses showed the following results. Postoperative day three: presence of inflammatory infiltrate, erythrocytes and proliferating fibroblasts in T, C - and C + samples. Day seven: extensive bone neoformation in groups T and C + , and beginning of alpha-TCP resorption by phagocytic cells. Days 14 and 21: osteoblastic activity in the three types of cavities. Day 60: In all samples, neoformed bone similar to surrounding bone. Moderate interruption on the ostectomized cortical bone. Conclusions: Bone neoformation is seen seven days after implantation of alpha-TCP and autogenous bone. Comparison of C - with T and C + samples showed that repair is faster in implanted cavities; on day 60, control groups presented almost complete bone repair. Alpha-TCP cement presents biocompatibility and osteotransductivity, besides stability, but 60 days after surgery the cavities were not closed. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Head & Face Medicine [recurso eletrônico]. London. Vol. 6, (28 June 2010), 8 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Materiais biocompatíveis | pt_BR |
dc.subject | Regeneração óssea | pt_BR |
dc.subject | Cimentos | pt_BR |
dc.subject | Enxerto osseo | pt_BR |
dc.title | Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graft | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000781489 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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