Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
dc.contributor.author | Demontis, Ditte | pt_BR |
dc.contributor.author | Bau, Claiton Henrique Dotto | pt_BR |
dc.contributor.author | Rovaris, Diego Luiz | pt_BR |
dc.contributor.author | Grevet, Eugenio Horácio | pt_BR |
dc.contributor.author | Rohde, Luis Augusto Paim | pt_BR |
dc.contributor.author | Hutz, Mara Helena | pt_BR |
dc.contributor.author | Andreassen, Ole A. | pt_BR |
dc.contributor.author | Pan, Pedro Mario | pt_BR |
dc.contributor.author | Banaschewski, Tobias | pt_BR |
dc.contributor.author | Børglum, Anders Dupont | pt_BR |
dc.date.accessioned | 2023-11-04T03:33:29Z | pt_BR |
dc.date.issued | 2023 | pt_BR |
dc.identifier.issn | 1546-1718 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/266589 | pt_BR |
dc.description.abstract | Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loci, highlighting 76 potential risk genes enriched among genes expressed particularly in early brain development. Overall, ADHD genetic risk was associated with several brain-specific neuronal subtypes and midbrain dopaminergic neurons. In exome-sequencing data from 17,896 individuals, we identified an increased load of rare protein-truncating variants in ADHD for a set of risk genes enriched with probable causal common variants, potentially implicating SORCS3 in ADHD by both common and rare variants. Bivariate Gaussian mixture modeling estimated that 84–98% of ADHD-influencing variants are shared with other psychiatric disorders. In addition, common-variant ADHD risk was associated with impaired complex cognition such as verbal reasoning and a range of executive functions, including attention. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Nature genetic. New York. Vol. 55. n. 2 (2023), p. 198–208 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Neurodevelopmental disorder | en |
dc.subject | Déficit de atenção | pt_BR |
dc.subject | Hiperatividade | pt_BR |
dc.title | Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001175780 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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