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dc.contributor.authorDemontis, Dittept_BR
dc.contributor.authorBau, Claiton Henrique Dottopt_BR
dc.contributor.authorRovaris, Diego Luizpt_BR
dc.contributor.authorGrevet, Eugenio Horáciopt_BR
dc.contributor.authorRohde, Luis Augusto Paimpt_BR
dc.contributor.authorHutz, Mara Helenapt_BR
dc.contributor.authorAndreassen, Ole A.pt_BR
dc.contributor.authorPan, Pedro Mariopt_BR
dc.contributor.authorBanaschewski, Tobiaspt_BR
dc.contributor.authorBørglum, Anders Dupontpt_BR
dc.date.accessioned2023-11-04T03:33:29Zpt_BR
dc.date.issued2023pt_BR
dc.identifier.issn1546-1718pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/266589pt_BR
dc.description.abstractAttention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loci, highlighting 76 potential risk genes enriched among genes expressed particularly in early brain development. Overall, ADHD genetic risk was associated with several brain-specific neuronal subtypes and midbrain dopaminergic neurons. In exome-sequencing data from 17,896 individuals, we identified an increased load of rare protein-truncating variants in ADHD for a set of risk genes enriched with probable causal common variants, potentially implicating SORCS3 in ADHD by both common and rare variants. Bivariate Gaussian mixture modeling estimated that 84–98% of ADHD-influencing variants are shared with other psychiatric disorders. In addition, common-variant ADHD risk was associated with impaired complex cognition such as verbal reasoning and a range of executive functions, including attention.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofNature genetic. New York. Vol. 55. n. 2 (2023), p. 198–208pt_BR
dc.rightsOpen Accessen
dc.subjectNeurodevelopmental disorderen
dc.subjectDéficit de atençãopt_BR
dc.subjectHiperatividadept_BR
dc.titleGenome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domainspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001175780pt_BR
dc.type.originEstrangeiropt_BR


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