Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models
dc.contributor.author | Reckziegel, Ramiro de Freitas Xavier | pt_BR |
dc.contributor.author | Czepielewski, Letícia Sanguinetti | pt_BR |
dc.contributor.author | Sousa, Mathias Hasse de | pt_BR |
dc.contributor.author | Martins, Dayane Santos | pt_BR |
dc.contributor.author | Britto, Maria J. de | pt_BR |
dc.contributor.author | Lapa, Clara de Oliveira | pt_BR |
dc.contributor.author | Schwartzhaupt, Alexandre Willi | pt_BR |
dc.contributor.author | Gama, Clarissa Severino | pt_BR |
dc.date.accessioned | 2023-03-11T03:28:17Z | pt_BR |
dc.date.issued | 2022 | pt_BR |
dc.identifier.issn | 1516-4446 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/255590 | pt_BR |
dc.description.abstract | The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Revista brasileira de psiquiatria (1999). São Paulo. Vol. 44, n. 1 (jan./feb. 2022), p. 74-80 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Esquizofrenia | pt_BR |
dc.subject | Schizophrenia | en |
dc.subject | Envelhecimento | pt_BR |
dc.subject | Cognition | en |
dc.subject | Aging | en |
dc.subject | Processos cognitivos | pt_BR |
dc.subject | Neurodevelopment | en |
dc.subject | Neuroprogression | en |
dc.title | Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001162615 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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