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dc.contributor.authorMorais, Rahuany Velleda dept_BR
dc.contributor.authorSouza, Meriene Viquetti dept_BR
dc.contributor.authorSilva, Klerize Anecely de Souzapt_BR
dc.contributor.authorSantiago, Pablopt_BR
dc.contributor.authorLorenzoni, Marcelo Cunhapt_BR
dc.contributor.authorLorea, Cecília Fernandespt_BR
dc.contributor.authorCastro Junior, Cláudio Galvão dept_BR
dc.contributor.authorTaniguchi, Adriano Nori Rodriguespt_BR
dc.contributor.authorScherer, Fernanda Fetterpt_BR
dc.contributor.authorMichalowski, Mariana Bohnspt_BR
dc.contributor.authorDaudt, Liane Estevespt_BR
dc.date.accessioned2022-01-27T04:31:01Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn0021-7557pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/234487pt_BR
dc.description.abstractObjective: This study aims to describe the epidemiological characteristics and survival rates of children with acute myeloid leukemia treated in hospitals in southern Brazil and compare them with international data. Methods: A multicenter cohort study was conducted with retrospective data collection of all new patients with acute myeloid leukemia under 18 treated at five referral centers in pediatric hematology-oncology in southern Brazil between January 2005 and December 2015. Results: Of the 149 patients with acute myeloid leukemia, 63.0% (n = 94) were male. The median age at diagnosis was 10.5 years (range 0-18 years) and 40.3% (n = 60) had a white blood cell count below 50,000/mm2. The most common Franco-American-British (FAB) subtype was M3 (n = 43, 28.9%). Nine (6.0%) patients had central nervous system disease. In M3 patients, overall survival (OS) was 69.2% and 3-year event-free survival was 67.7%; in non-M3 patients, these rates were 45.3% and 36.7%, respectively. In non-M3 patients, OS was significantly different between transplanted (61.8%) and non-transplanted (38.2%) patients (p = 0.031). Conclusions: These results show a higher prevalence of the Franco-American-British M3 subtype than that reported in the international literature, as well as a decreased OS compared with that of developed countries. Further multicenter Brazilian studies with a larger sample size are encouraged to better understand the characteristics of acute myeloid leukemia, and to improve the treatment and prognosis in this population.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofJornal de pediatria. Rio de Janeiro. Vol. 97 (2021), p. 204-210pt_BR
dc.rightsOpen Accessen
dc.subjectAcute myeloid leukemiaen
dc.subjectLeucemia mielóide agudapt_BR
dc.subjectEpidemiologiapt_BR
dc.subjectEpidemiologyen
dc.subjectCriançapt_BR
dc.subjectChildhooden
dc.titleEpidemiological evaluation and survival of children with acute myeloid leukemiapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001135883pt_BR
dc.type.originNacionalpt_BR


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