Epidemiological evaluation and survival of children with acute myeloid leukemia
dc.contributor.author | Morais, Rahuany Velleda de | pt_BR |
dc.contributor.author | Souza, Meriene Viquetti de | pt_BR |
dc.contributor.author | Silva, Klerize Anecely de Souza | pt_BR |
dc.contributor.author | Santiago, Pablo | pt_BR |
dc.contributor.author | Lorenzoni, Marcelo Cunha | pt_BR |
dc.contributor.author | Lorea, Cecília Fernandes | pt_BR |
dc.contributor.author | Castro Junior, Cláudio Galvão de | pt_BR |
dc.contributor.author | Taniguchi, Adriano Nori Rodrigues | pt_BR |
dc.contributor.author | Scherer, Fernanda Fetter | pt_BR |
dc.contributor.author | Michalowski, Mariana Bohns | pt_BR |
dc.contributor.author | Daudt, Liane Esteves | pt_BR |
dc.date.accessioned | 2022-01-27T04:31:01Z | pt_BR |
dc.date.issued | 2021 | pt_BR |
dc.identifier.issn | 0021-7557 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/234487 | pt_BR |
dc.description.abstract | Objective: This study aims to describe the epidemiological characteristics and survival rates of children with acute myeloid leukemia treated in hospitals in southern Brazil and compare them with international data. Methods: A multicenter cohort study was conducted with retrospective data collection of all new patients with acute myeloid leukemia under 18 treated at five referral centers in pediatric hematology-oncology in southern Brazil between January 2005 and December 2015. Results: Of the 149 patients with acute myeloid leukemia, 63.0% (n = 94) were male. The median age at diagnosis was 10.5 years (range 0-18 years) and 40.3% (n = 60) had a white blood cell count below 50,000/mm2. The most common Franco-American-British (FAB) subtype was M3 (n = 43, 28.9%). Nine (6.0%) patients had central nervous system disease. In M3 patients, overall survival (OS) was 69.2% and 3-year event-free survival was 67.7%; in non-M3 patients, these rates were 45.3% and 36.7%, respectively. In non-M3 patients, OS was significantly different between transplanted (61.8%) and non-transplanted (38.2%) patients (p = 0.031). Conclusions: These results show a higher prevalence of the Franco-American-British M3 subtype than that reported in the international literature, as well as a decreased OS compared with that of developed countries. Further multicenter Brazilian studies with a larger sample size are encouraged to better understand the characteristics of acute myeloid leukemia, and to improve the treatment and prognosis in this population. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Jornal de pediatria. Rio de Janeiro. Vol. 97 (2021), p. 204-210 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Acute myeloid leukemia | en |
dc.subject | Leucemia mielóide aguda | pt_BR |
dc.subject | Epidemiologia | pt_BR |
dc.subject | Epidemiology | en |
dc.subject | Criança | pt_BR |
dc.subject | Childhood | en |
dc.title | Epidemiological evaluation and survival of children with acute myeloid leukemia | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001135883 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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