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dc.contributor.authorCechim, Giovanapt_BR
dc.contributor.authorEllwanger, Joel Henriquept_BR
dc.contributor.authorKaminski, Valéria de Limapt_BR
dc.contributor.authorBerger, Miltonpt_BR
dc.contributor.authorChies, Jose Artur Bogopt_BR
dc.date.accessioned2021-12-29T04:27:19Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn2357-9730pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/233453pt_BR
dc.description.abstractIntroduction: Renal cell carcinoma (RCC) is one of the most prevalent kidney tumors. Inflammation is believed to be a key factor in its progression and spread since inflammatory markers are generally associated with poor prognosis in RCC patients. Cytokines are cell communication molecules involved in both healthy and pathological processes, including tumor growth and progression. Recent findings suggest that cytokine level measurements could be used for cancer monitoring and prognosis. Methods: This study characterized and compared the levels of different cytokines associated with the classical Th1, Th2, and Th17 immune responses in plasma samples from RCC patients (n = 25) and healthy controls (n = 29). Cytokine levels (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ, and IL-17A) were evaluated by flow cytometry using a BD Cytometric Bead Array (CBA) kit. Results: No statistical differences in systemic IL-2, IL-4, IL-10, IL-17A, TNF, and INF-γ levels were observed between RCC patients and controls (p > 0.05). However, higher systemic IL-6 levels were observed in RCC patients (p = 0.0034). Conclusions: This study highlights the importance of assessing the impact of IL-6 on RCC pathogenesis and its potential role as a biomarker of disease progression.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofClinical and biomedical research. Porto Alegre. Vol. 41, no. 3 (2021), p. 205-211pt_BR
dc.rightsOpen Accessen
dc.subjectCitometria de fluxopt_BR
dc.subjectCytometric Bead Array (CBA)en
dc.subjectCytokinesen
dc.subjectCitocinaspt_BR
dc.subjectIL-6en
dc.subjectInflamaçãopt_BR
dc.subjectInflammationen
dc.subjectNeoplasias renaispt_BR
dc.subjectRenal canceren
dc.titleIncreased systemic IL-6 levels point to inflammation as a determinant of renal cell carcinoma developmentpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001134281pt_BR
dc.type.originNacionalpt_BR


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