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dc.contributor.authorVogt, Éverton Lopespt_BR
dc.contributor.authorDentz, Maiza Cristina Vonpt_BR
dc.contributor.authorRocha, Débora Santospt_BR
dc.contributor.authorModel, Jorge Felipe Argentapt_BR
dc.contributor.authorKowalewski, Lucas Stahlhöferpt_BR
dc.contributor.authorSouza, Samir Kahl dept_BR
dc.contributor.authorOliveira, Vitória Girelli dept_BR
dc.contributor.authorBittencourt Junior, Paulo Ivo Homem dept_BR
dc.contributor.authorFriedman, Rogériopt_BR
dc.contributor.authorKrause, Maurício da Silvapt_BR
dc.contributor.authorVinagre, Anapaula Sommerpt_BR
dc.date.accessioned2021-09-03T04:27:40Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn1660-4601pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/229531pt_BR
dc.description.abstractIntroduction and objectives: Obesity represents a major global public health problem. Its etiology is multifactorial and includes poor dietary habits, such as hypercaloric and hyperlipidic diets (HFDs), physical inactivity, and genetic factors. Regular exercise is, per se, a tool for the treatment and prevention of obesity, and recent studies suggest that the beneficial effects of exercise can be potentiated by the fasting state, thus potentially promoting additional effects. Despite the significant number of studies showing results that corroborate such hypothesis, very few have evaluated the effects of fasted-state exercise in overweight/obese populations. Therefore, the aim of this study was to evaluate the subacute effects (12 h after conclusion) of a single moderate-intensity exercise bout, performed in either a fed or an 8 h fasted state, on serum profile, substrate-content and heat shock pathway–related muscle protein immunocontent in obese male rats. Methods: Male Wistar rats received a modified high-fat diet for 12 weeks to induce obesity and insulin resistance. The animals were allocated to four groups: fed rest (FER), fed exercise (FEE), fasted rest (FAR) and fasted exercise (FAE). The exercise protocol was a 30 min session on a treadmill, with an intensity of 60% of VO2max. The duration of the fasting period was 8 h prior to the exercise session. After a 12 h recovery, the animals were killed and metabolic parameters of blood, liver, heart, gastrocnemius and soleus muscles were evaluated, as well as SIRT1 and HSP70 immunocontent in the muscles. Results: HFD induced obesity and insulin resistance. Soleus glycogen concentration decreased in the fasted groups and hepatic glycogen decreased in the fed exercise group. The combination of exercise and fasting promoted a decreased concentration of serum total cholesterol and triglycerides. In the heart, combination fasting plus exercise was able to decrease triglycerides to control levels. In the soleus muscle, both fasting and fasting plus exercise were able to decrease triglyceride concentrations. In addition, heat shock protein 70 and sirtuin 1 immunocontent increased after exercise in the gastrocnemius and soleus muscles. Conclusions: An acute bout of moderate intensity aerobic exercise, when realized in fasting, may induce, in obese rats with metabolic dysfunctions, beneficial adaptations to their health, such as better biochemical and molecular adaptations that last for at least 12 h. Considering the fact that overweight/obese populations present an increased risk of cardiovascular events/diseases, significant reductions in such plasma markers of lipid metabolism are an important achievement for these populations.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofInternational journal of environmental research and public health. Basel. Vol. 18, no. 14 (July 2021), 7543, 17 p.pt_BR
dc.rightsOpen Accessen
dc.subjectFastingen
dc.subjectObesidadept_BR
dc.subjectAerobic exerciseen
dc.subjectExercício físicopt_BR
dc.subjectObesityen
dc.subjectResistência à insulinapt_BR
dc.subjectJejumpt_BR
dc.subjectMetabolismen
dc.subjectInflammationen
dc.subjectDieta hiperlipidicapt_BR
dc.titleMetabolic and molecular subacute effects of a single moderate-intensity exercise bout, performed in the fasted state, in obese male ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001130675pt_BR
dc.type.originEstrangeiropt_BR


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