Protective effect of N-acetyl-L-cysteine and rosuvastatin against oxidative stress in fibroblasts from asymptomatic patients with X-ALD : a preliminary study
dc.contributor.author | Marchetti, Desirèe Padilha | pt_BR |
dc.contributor.author | Ribas, Graziela de Oliveira Schmitt | pt_BR |
dc.contributor.author | Donida, Bruna | pt_BR |
dc.contributor.author | Brito, Verônica Bidinotto | pt_BR |
dc.contributor.author | Moura, Dinara Jaqueline | pt_BR |
dc.contributor.author | Coelho, Daniella de Moura | pt_BR |
dc.contributor.author | Machado, Andryele Zaffari | pt_BR |
dc.contributor.author | Kessler, Rejane Gus | pt_BR |
dc.contributor.author | Coitinho, Adriana Simon | pt_BR |
dc.contributor.author | Vargas, Carmen Regla | pt_BR |
dc.date.accessioned | 2021-08-05T04:31:10Z | pt_BR |
dc.date.issued | 2021 | pt_BR |
dc.identifier.issn | 2357-9730 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/225215 | pt_BR |
dc.description.abstract | Introduction: Several studies in the literature have evaluated the role of oxidative stress and adjuvant therapies for X-linked adrenoleukodystrophy (X-ALD). Here, we investigated whether n-acetyl-L-cysteine (NAC) and rosuvastatin (RSV) could influence the generation of reactive species, redox status and nitrative stress in fibroblasts from asymptomatic patients with X-ALD. Methods: Skin biopsy samples were cultured and treated for 2 hours (37 °C) with NAC and RSV. Results: X-ALD fibroblasts generated high levels of reactive oxygen species. These levels were significantly lower in fibroblasts treated with NAC and RSV relative to untreated samples. The X-ALD fibroblasts from asymptomatic patients also had higher catalase activity, and only NAC was able to increase enzyme activity in the samples. Conclusions: Our results indicated that NAC and RSV were able to improve oxidative stress parameters in fibroblasts from asymptomatic patients with X-ALD, showing that adjuvant antioxidant therapy may be a promising treatment strategy for asymptomatic patients with this disease. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Clinical and biomedical research. Porto Alegre. vol. 41, no. 1 (2021), p. 57-64 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Estresse oxidativo | pt_BR |
dc.subject | X-linked adrenoleukodystrophy | en |
dc.subject | Acetilcisteína | pt_BR |
dc.subject | Fibroblasts | en |
dc.subject | Adrenoleucodistrofia | pt_BR |
dc.subject | N-acetyl-L-cysteine | en |
dc.subject | Rosuvastatin | en |
dc.subject | Rosuvastatina cálcica | pt_BR |
dc.subject | Oxidative stress | en |
dc.title | Protective effect of N-acetyl-L-cysteine and rosuvastatin against oxidative stress in fibroblasts from asymptomatic patients with X-ALD : a preliminary study | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001129131 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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