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dc.contributor.authorPaula, Tatiana Pedroso dept_BR
dc.contributor.authorMoreira, Juliano Soares Rabellopt_BR
dc.contributor.authorSperb, Luiza Ferreirapt_BR
dc.contributor.authorMuller, Maria Elisa P.pt_BR
dc.contributor.authorSteemburgo, Thaispt_BR
dc.contributor.authorViana, Luciana Verçozapt_BR
dc.date.accessioned2020-12-24T04:21:51Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/216897pt_BR
dc.description.abstractObservational and experimental data reinforce the concept that vitamin D is associated with the pathogenesis of arterial hypertension. We investigated the efect of a single dose of 100,000 IU of cholecalciferol, in ofce blood pressure (BP), and 24-h ambulatory blood pressure monitoring (ABPM) in patients with type 2 diabetes mellitus (DM), hypertension, and hypovitaminosis D. Fortythree patients were randomized to a placebo or cholecalciferol group. BP was assessed by ofce measurements and 24-h ABPM, before and after intervention. At week 8, a greater decrease in median ABPM values was observed in cholecalciferol supplementation than in the placebo group for systolic 24-h (− 7.5 vs. − 1; P= 0.02), systolic daytime (− 7 vs. − 1; P= 0.007), systolic nighttime (− 7.0 vs. 3; P= 0.009), diastolic 24-h (− 3.5 vs. − 1; P= 0.037), and daytime DBP (− 5 vs. 0; P= 0.01). Ofce DBP was also reduced after vitamin D supplementation. A single dose of vitamin D3 improves BP in patients with type 2 diabetes, hypertension, and vitamin D insufciency, regardless of vitamin D normalization. Vitamin D supplementation could be a valuable tool to treat patients with type 2 DM, hypertension, and hypovitaminosis D.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofScientific reports. London. Vol. 10 (2020), 19611, 8 p.pt_BR
dc.rightsOpen Accessen
dc.subjectPressão sanguíneapt_BR
dc.subjectHipertensãopt_BR
dc.subjectDiabetes mellitus tipo 2pt_BR
dc.subjectVitamina Dpt_BR
dc.subjectColecalciferolpt_BR
dc.titleEfficacy of single-dose cholecalciferol in the blood pressure of patients with type 2 diabetes, hypertension and hypovitaminoses Dpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001120025pt_BR
dc.type.originEstrangeiropt_BR


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