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Efficacy of single-dose cholecalciferol in the blood pressure of patients with type 2 diabetes, hypertension and hypovitaminoses D
dc.contributor.author | Paula, Tatiana Pedroso de | pt_BR |
dc.contributor.author | Moreira, Juliano Soares Rabello | pt_BR |
dc.contributor.author | Sperb, Luiza Ferreira | pt_BR |
dc.contributor.author | Muller, Maria Elisa P. | pt_BR |
dc.contributor.author | Steemburgo, Thais | pt_BR |
dc.contributor.author | Viana, Luciana Verçoza | pt_BR |
dc.date.accessioned | 2020-12-24T04:21:51Z | pt_BR |
dc.date.issued | 2020 | pt_BR |
dc.identifier.issn | 2045-2322 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/216897 | pt_BR |
dc.description.abstract | Observational and experimental data reinforce the concept that vitamin D is associated with the pathogenesis of arterial hypertension. We investigated the efect of a single dose of 100,000 IU of cholecalciferol, in ofce blood pressure (BP), and 24-h ambulatory blood pressure monitoring (ABPM) in patients with type 2 diabetes mellitus (DM), hypertension, and hypovitaminosis D. Fortythree patients were randomized to a placebo or cholecalciferol group. BP was assessed by ofce measurements and 24-h ABPM, before and after intervention. At week 8, a greater decrease in median ABPM values was observed in cholecalciferol supplementation than in the placebo group for systolic 24-h (− 7.5 vs. − 1; P= 0.02), systolic daytime (− 7 vs. − 1; P= 0.007), systolic nighttime (− 7.0 vs. 3; P= 0.009), diastolic 24-h (− 3.5 vs. − 1; P= 0.037), and daytime DBP (− 5 vs. 0; P= 0.01). Ofce DBP was also reduced after vitamin D supplementation. A single dose of vitamin D3 improves BP in patients with type 2 diabetes, hypertension, and vitamin D insufciency, regardless of vitamin D normalization. Vitamin D supplementation could be a valuable tool to treat patients with type 2 DM, hypertension, and hypovitaminosis D. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Scientific reports. London. Vol. 10 (2020), 19611, 8 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Pressão sanguínea | pt_BR |
dc.subject | Hipertensão | pt_BR |
dc.subject | Diabetes mellitus tipo 2 | pt_BR |
dc.subject | Vitamina D | pt_BR |
dc.subject | Colecalciferol | pt_BR |
dc.title | Efficacy of single-dose cholecalciferol in the blood pressure of patients with type 2 diabetes, hypertension and hypovitaminoses D | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001120025 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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