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dc.contributor.authorPicon, Paulo Dornellespt_BR
dc.contributor.authorGonçalves, Sandro Cadavalpt_BR
dc.contributor.authorWainstein, Marco Vugmanpt_BR
dc.contributor.authorCosta, Andry Fitermanpt_BR
dc.contributor.authorMengarda, Claudia Vieirapt_BR
dc.contributor.authorMachado, R.P.pt_BR
dc.contributor.authorBerlim, Gustavo Levacovpt_BR
dc.contributor.authorEdelweiss, Marciapt_BR
dc.contributor.authorEdelweiss, Maria Isabel Albanopt_BR
dc.contributor.authorRibeiro, Jorge Pintopt_BR
dc.date.accessioned2010-04-24T04:15:49Zpt_BR
dc.date.issued1997pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21222pt_BR
dc.description.abstractAcute thrombosis can be induced in rabbits by a triggering protocol using Russell’s viper venom and histamine given after 8 months of a 1% cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aortic desendothelization performed 4 months before the triggering protocol without a high cholesterol diet is a highly effective and less expensive way of producing arterial atherosclerosis and thrombosis. Nineteen male New Zealand white rabbits on a normal diet were studied. The control group (N = 9) received no intervention during the 4-month observation period, while the other group (N = 10) was submitted to aortic balloon desendothelization using a 4F Fogarty catheter. At the end of this period, all animals were killed 48 h after receiving the first dose of the triggering treatment. Eight of 10 rabbits (80%) in the balloon-trauma group presented platelet-rich arterial thrombosis while none of the animals in the control group had thrombus formation (P<0.01). Thus, this model, using balloon desendothelization without dietary manipulation, induces arterial atherosclerosis and thrombosis and may provide possibilities to test new therapeutic approaches.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 30, n. 3 (mar. 1997), p. 415-417pt_BR
dc.rightsOpen Accessen
dc.subjectEndotheliumen
dc.subjectAterosclerosept_BR
dc.subjectTrombose coronáriapt_BR
dc.subjectHistamineen
dc.subjectEndotélio vascularpt_BR
dc.subjectRussell's viper venomen
dc.subjectCoronary artery diseaseen
dc.subjectAngioplastiapt_BR
dc.subjectCoelhospt_BR
dc.titleAtherosclerosis and acute arterial thrombosis in rabbits : a model using balloon desendothelization without dietary interventionpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000652300pt_BR
dc.type.originNacionalpt_BR


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