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Atherosclerosis and acute arterial thrombosis in rabbits : a model using balloon desendothelization without dietary intervention
dc.contributor.author | Picon, Paulo Dornelles | pt_BR |
dc.contributor.author | Gonçalves, Sandro Cadaval | pt_BR |
dc.contributor.author | Wainstein, Marco Vugman | pt_BR |
dc.contributor.author | Costa, Andry Fiterman | pt_BR |
dc.contributor.author | Mengarda, Claudia Vieira | pt_BR |
dc.contributor.author | Machado, R.P. | pt_BR |
dc.contributor.author | Berlim, Gustavo Levacov | pt_BR |
dc.contributor.author | Edelweiss, Marcia | pt_BR |
dc.contributor.author | Edelweiss, Maria Isabel Albano | pt_BR |
dc.contributor.author | Ribeiro, Jorge Pinto | pt_BR |
dc.date.accessioned | 2010-04-24T04:15:49Z | pt_BR |
dc.date.issued | 1997 | pt_BR |
dc.identifier.issn | 0100-879X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/21222 | pt_BR |
dc.description.abstract | Acute thrombosis can be induced in rabbits by a triggering protocol using Russell’s viper venom and histamine given after 8 months of a 1% cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aortic desendothelization performed 4 months before the triggering protocol without a high cholesterol diet is a highly effective and less expensive way of producing arterial atherosclerosis and thrombosis. Nineteen male New Zealand white rabbits on a normal diet were studied. The control group (N = 9) received no intervention during the 4-month observation period, while the other group (N = 10) was submitted to aortic balloon desendothelization using a 4F Fogarty catheter. At the end of this period, all animals were killed 48 h after receiving the first dose of the triggering treatment. Eight of 10 rabbits (80%) in the balloon-trauma group presented platelet-rich arterial thrombosis while none of the animals in the control group had thrombus formation (P<0.01). Thus, this model, using balloon desendothelization without dietary manipulation, induces arterial atherosclerosis and thrombosis and may provide possibilities to test new therapeutic approaches. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 30, n. 3 (mar. 1997), p. 415-417 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Endothelium | en |
dc.subject | Aterosclerose | pt_BR |
dc.subject | Trombose coronária | pt_BR |
dc.subject | Histamine | en |
dc.subject | Endotélio vascular | pt_BR |
dc.subject | Russell's viper venom | en |
dc.subject | Coronary artery disease | en |
dc.subject | Angioplastia | pt_BR |
dc.subject | Coelhos | pt_BR |
dc.title | Atherosclerosis and acute arterial thrombosis in rabbits : a model using balloon desendothelization without dietary intervention | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000652300 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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