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dc.contributor.authorLopes, Bettega Costapt_BR
dc.contributor.authorMedeiros, Liciane Fernandespt_BR
dc.contributor.authorSouza, Vanessa Silva dept_BR
dc.contributor.authorCioato, Stefania Giottipt_BR
dc.contributor.authorMedeiros, Helouise Richardtpt_BR
dc.contributor.authorRegner, Gabriela Gregorypt_BR
dc.contributor.authorOliveira, Camila Lino dept_BR
dc.contributor.authorFregni, Felipept_BR
dc.contributor.authorCaumo, Wolneipt_BR
dc.contributor.authorTorres, Iraci Lucena da Silvapt_BR
dc.date.accessioned2020-06-20T03:41:18Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn1876-4754pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/210478pt_BR
dc.description.abstractBackground: Behavioral alterations, like mechanical and thermal hyperalgesia, and modulation of biomarkers in the peripheral and central nervous systems (CNS) are markers of chronic pain. Transcranial direct current stimulation (tDCS) with exercise is a promising therapy for pain due to its neuromodulatory capacity. Objective: To assess the individual effects of tDCS, exercise, and the two combined on the nociceptive response and BDNF, IL-1b, and IL-4 levels in the CNS structures of rats in a chronic pain model. Methods: For 8 consecutive days after the establishment of chronic neuropathic pain by inducing a constriction injury to the sciatic nerve (CCI), the rats received tDCS, exercise, or both treatments combined (20 min/day). The hyperalgesic response was assessed by von Frey and hot plate tests at baseline, 7, and 14 days after CCI surgery and immediately, 24 h, and 7 days after the end of treatment. The BDNF, IL1b, and IL-4 levels were assessed in the cerebral cortex, brainstem, and spinal cord by enzyme-linked immunosorbent assay at 48 h and 7 days after the end of treatment. Results: The CCI model triggered marked mechanical and thermal hyperalgesia. However, bimodal tDCS, aerobic exercise, and the two combined relieved nociceptive behavior for up to 7 days following treatment completion. Conclusions: Bimodal tDCS, aerobic exercise, or both treatments combined promoted analgesic effects for neuropathic pain. Such effects were reflected by cytokine modulation throughout the spinal cordbrainstem-cerebral cortex axis.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBrain stimulation. New York. Vol.13, no. 3 (2020), p.774-782pt_BR
dc.rightsOpen Accessen
dc.subjectBimodal tDCSen
dc.subjectExercíciopt_BR
dc.subjectEstimulação transcraniana por corrente contínuapt_BR
dc.subjectAerobic exerciseen
dc.subjectNeuropathic painen
dc.subjectDorpt_BR
dc.subjectCytokinesen
dc.subjectCitocinaspt_BR
dc.subjectRatsen
dc.subjectInflamaçãopt_BR
dc.subjectHiperalgesiapt_BR
dc.subjectModelos animaispt_BR
dc.titleTranscranial direct current stimulation combined with exercise modulates the inflammatory profile and hyperalgesic response in rats subjected to a neuropathic pain model : long-term effectspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001114264pt_BR
dc.type.originEstrangeiropt_BR


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