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dc.contributor.authorHerber, Silvanipt_BR
dc.contributor.authorTerra, Anna Pirespt_BR
dc.contributor.authorSilva, André Anjos dapt_BR
dc.contributor.authorSanseverino, Maria Teresa Vieirapt_BR
dc.contributor.authorFraga, Lucas Rosapt_BR
dc.contributor.authorVianna, Fernanda Sales Luizpt_BR
dc.contributor.authorSchwartz, Ida Vanessa Doederleinpt_BR
dc.contributor.authorFaccini, Lavinia Schulerpt_BR
dc.contributor.authorFriedrich, Lucianapt_BR
dc.date.accessioned2020-02-22T04:21:26Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn2357-9730pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/206217pt_BR
dc.description.abstractIntroduction: Microcephaly is a clinical finding that can arise from congenital anomalies or emerge after childbirth. Maternal infections acquired during pregnancy can result in characteristic brain damage in the newborn (NB), which may be visible even in the fetal stage. To describe the epidemiological profile of newborns with reported microcephaly and diagnosed with congenital infections in the state of Rio Grande do Sul between 2015 and 2017. Methods: A cross-sectional study was carried out on data collected from the Public Health Event Registry as well as from medical records. The investigation included serologies for toxoplasmosis and rubella; polymerase chain reaction (PCR) for Zika virus (ZIKV) in the blood and cytomegalovirus in the urine; non-treponemal tests for syphilis; and brain imaging tests. Results: Of the 257 reported cases of microcephaly, 39 were diagnosed with congenital infections. Severe microcephaly was identified in 13 patients (33.3%) and 51.3% of the cases showed alterations in brain imaging tests. In relation to the diagnosis of congenital infections, three patients (7.7%) were diagnosed with ZIKV, nine (23.1%) with cytomegalovirus, nine (23.1%) with toxoplasmosis, and 18 (46.1%) with congenital syphilis. The three cases of ZIKV showed calcification in brain imaging tests, signs of arthrogryposis, excess occipital skin and irritability, characterizing the typical phenotype of ZIKV infection. Conclusions: Most cases of congenital infection had severe neurological lesions, particularly the cases of ZIKV, which can cause neurodevelopmental delays and sequelae in these infants throughout early childhood.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofClinical and biomedical research. Vol. 39, no. 3 (2019), p. 200-208pt_BR
dc.rightsOpen Accessen
dc.subjectInfecção por Zika viruspt_BR
dc.subjectMicrocephalyen
dc.subjectMicrocefaliapt_BR
dc.subjectCngenital infectionen
dc.subjectZika virusen
dc.subjectEpidemiologiapt_BR
dc.subjectRio Grande do Sulpt_BR
dc.titleEpidemiological profile of 39 cases of microcephaly caused by congenital infections diagnosed in the state of Rio Grande do Sul between 2015-2017pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001112566pt_BR
dc.type.originNacionalpt_BR


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