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dc.contributor.authorChedid, Márcio Fernandespt_BR
dc.contributor.authorNascimento, Filipe Valvassori dopt_BR
dc.contributor.authorOliveira, Fernanda Santos dept_BR
dc.contributor.authorSouza, Bianca Marmontel dept_BR
dc.contributor.authorKruel, Cleber Rosito Pintopt_BR
dc.contributor.authorGurski, Richard Ricachenevskypt_BR
dc.contributor.authorCanani, Luis Henrique Santospt_BR
dc.contributor.authorCrispim, Daisypt_BR
dc.contributor.authorGerchman, Fernandopt_BR
dc.date.accessioned2020-02-13T04:22:44Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn1758-5996pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/205854pt_BR
dc.description.abstractBackground: The enzyme 11-beta hydroxysteroid dehydrogenase type 1 (HSD11B1) converts inactive cortisone to active cortisol in a process mediated by the enzyme hexose-6-phosphate dehydrogenase (H6PD). The generation of cortisol from this reaction may increase intra-abdominal cortisol levels and contribute to the physiopathogenesis of obesity and metabolic syndrome (MetS). The relationship of HSD11B1 rs45487298 and H6PD rs6688832 polymorphisms with obesity and MetS was studied. We also studied how HSD11B1 abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) gene expression is related to body fat distribution. Methods: Rates of obesity and MetS features were cross-sectionally analyzed according to these polymorphisms in 1006 Brazilian white patients with type 2 diabetes (T2DM). Additionally, HSD11B1 expression was analyzed in VAT and SAT in a diferent cohort of 28 participants with and without obesity who underwent elective abdominal operations. Results: Although polymorphisms of the two genes were not individually associated with MetS features, a synergistic efect was observed between both. Carriers of at least three minor alleles exhibited lower BMI compared to those with two or fewer minor alleles adjusting for gender and age (27.4±4.9 vs. 29.3±5.3 kg/m2 ; P=0.005; mean±SD). Obesity frequency was also lower in the frst group (24.4% vs. 41.6%, OR=0.43, 95% CI 0.21–0.87; P=0.019). In the second cohort of 28 subjects, HSD11B1 gene expression in VAT was inversely correlated with BMI (r=− 0.435, P=0.034), waist circumference (r=− 0.584, P=0.003) and waist-to-height ratio (r=− 0.526, P=0.010). Conclusions: These polymorphisms might interact in the protection against obesity in T2DM individuals. Obese individuals may have decreased intra-abdominal VAT HSD11B1 gene expression resulting in decreasing intra-abdominal cortisol levels as a compensatory mechanism against central and general adiposity.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofDiabetology and metabolic syndrome. London. Vol. 11 (2019), 78, 10 p.pt_BR
dc.rightsOpen Accessen
dc.subjectGene expressionen
dc.subjectExpressão gênicapt_BR
dc.subject11-beta hydroxysteroid dehydrogenase type 1en
dc.subjectHidrocortisonapt_BR
dc.subjectTecido adiposopt_BR
dc.subjectHexose-6-phosphate dehydrogenaseen
dc.subjectVisceralen
dc.subjectPolimorfismo genéticopt_BR
dc.subjectAdipose tissueen
dc.subjectPrognósticopt_BR
dc.subjectFatores de riscopt_BR
dc.subjectObesidadept_BR
dc.subject11-beta-hidroxiesteroide desidrogenase tipo 1pt_BR
dc.subjectGlucosefosfato desidrogenasept_BR
dc.subjectDiabetes mellitus tipo 2pt_BR
dc.titleInteraction of HSD11B1 and H6PD polymorphisms in subjects with type 2 diabetes are protective factors against obesity : a cross-sectional studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001110577pt_BR
dc.type.originEstrangeiropt_BR


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