Cerebral ketone body oxidation is facilitated by a high fat diet enriched with advanced glycation end products in normal and diabetic rats
dc.contributor.author | Assis, Adriano Martimbianco de | pt_BR |
dc.contributor.author | Silva, Jussemara Souza da | pt_BR |
dc.contributor.author | Rech, Anderson | pt_BR |
dc.contributor.author | Santos, Aline Longoni dos | pt_BR |
dc.contributor.author | Nonose, Yasmine | pt_BR |
dc.contributor.author | Repond, Cendrine | pt_BR |
dc.contributor.author | Pasquali, Matheus Augusto de Bittencourt | pt_BR |
dc.contributor.author | Moreira, Jose Claudio Fonseca | pt_BR |
dc.contributor.author | Souza, Diogo Onofre Gomes de | pt_BR |
dc.contributor.author | Pellerin, Luc | pt_BR |
dc.date.accessioned | 2019-09-04T02:34:46Z | pt_BR |
dc.date.issued | 2019 | pt_BR |
dc.identifier.issn | 1662-453X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/198760 | pt_BR |
dc.description.abstract | Diabetesmellitus(DM)causesimportantmodificationsintheavailabilityanduseofdifferentenergysubstratesinvariousorgansandtissues.Similarly,dietarymanipulationssuchashighfatdietsalsoaffectsystemicenergymetabolism.However,howthebrainadaptstothesesituationsremainsunclear.Toinvestigatetheseissues,controlandalloxan-inducedtypeIdiabeticratswerefedeitherastandardorahighfatdietenrichedwithadvancedglycationendproducts(AGEs)(HAGEdiet).TheHAGEdietincreasedtheirlevelsofbloodketonebodies,andthiseffectwasexacerbatedbyDMinduction.Todeterminetheeffectsofdietand/orDMinductiononkeycerebralbioenergeticparameters,bothketonebodies(b-hydroxybutyricacid)andlactateoxidationweremeasured.Inparallel,theexpressionofMonocarboxylateTransporter1(MCT1)and2(MCT2)isoformsinhippocampalandcorticalslicesfromratssubmittedtothesedietswasassessed.KetonebodyoxidationincreasedwhilelactateoxidationdecreasedinhippocampalandcorticalslicesinbothcontrolanddiabeticratsfedaHAGEdiet.Inparallel,theexpressionofbothMCT1andMCT2increasedonlyinthecerebralcortexindiabeticratsfedaHAGEdiet.TheseresultssuggestashiftinthepreferentialcerebralenergysubstrateutilizationinfavorofketonebodiesinanimalsfedaHAGEdiet,aneffectthat,inDManimals,isaccompaniedbytheenhancedexpressionoftherelatedtransporters. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Frontiers in neuroscience. Lausanne. Vol. 10 (Nov. 2019), 509, 7 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Diabetes mellitus | pt_BR |
dc.subject | Brainenergymetabolism | en |
dc.subject | Biabetesmellitus | en |
dc.subject | Transportadores de ácidos monocarboxílicos | pt_BR |
dc.subject | Highfatdiet | en |
dc.subject | Dieta hiperlipidica | pt_BR |
dc.subject | MCTs | en |
dc.subject | AGEs | en |
dc.title | Cerebral ketone body oxidation is facilitated by a high fat diet enriched with advanced glycation end products in normal and diabetic rats | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001099010 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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