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Cerebral ketone body oxidation is facilitated by a high fat diet enriched with advanced glycation end products in normal and diabetic rats

dc.contributor.authorAssis, Adriano Martimbianco dept_BR
dc.contributor.authorSilva, Jussemara Souza dapt_BR
dc.contributor.authorRech, Andersonpt_BR
dc.contributor.authorSantos, Aline Longoni dospt_BR
dc.contributor.authorNonose, Yasminept_BR
dc.contributor.authorRepond, Cendrinept_BR
dc.contributor.authorPasquali, Matheus Augusto de Bittencourtpt_BR
dc.contributor.authorMoreira, Jose Claudio Fonsecapt_BR
dc.contributor.authorSouza, Diogo Onofre Gomes dept_BR
dc.contributor.authorPellerin, Lucpt_BR
dc.date.accessioned2019-09-04T02:34:46Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn1662-453Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/198760pt_BR
dc.description.abstractDiabetesmellitus(DM)causesimportantmodificationsintheavailabilityanduseofdifferentenergysubstratesinvariousorgansandtissues.Similarly,dietarymanipulationssuchashighfatdietsalsoaffectsystemicenergymetabolism.However,howthebrainadaptstothesesituationsremainsunclear.Toinvestigatetheseissues,controlandalloxan-inducedtypeIdiabeticratswerefedeitherastandardorahighfatdietenrichedwithadvancedglycationendproducts(AGEs)(HAGEdiet).TheHAGEdietincreasedtheirlevelsofbloodketonebodies,andthiseffectwasexacerbatedbyDMinduction.Todeterminetheeffectsofdietand/orDMinductiononkeycerebralbioenergeticparameters,bothketonebodies(b-hydroxybutyricacid)andlactateoxidationweremeasured.Inparallel,theexpressionofMonocarboxylateTransporter1(MCT1)and2(MCT2)isoformsinhippocampalandcorticalslicesfromratssubmittedtothesedietswasassessed.KetonebodyoxidationincreasedwhilelactateoxidationdecreasedinhippocampalandcorticalslicesinbothcontrolanddiabeticratsfedaHAGEdiet.Inparallel,theexpressionofbothMCT1andMCT2increasedonlyinthecerebralcortexindiabeticratsfedaHAGEdiet.TheseresultssuggestashiftinthepreferentialcerebralenergysubstrateutilizationinfavorofketonebodiesinanimalsfedaHAGEdiet,aneffectthat,inDManimals,isaccompaniedbytheenhancedexpressionoftherelatedtransporters.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in neuroscience. Lausanne. Vol. 10 (Nov. 2019), 509, 7 p.pt_BR
dc.rightsOpen Accessen
dc.subjectDiabetes mellituspt_BR
dc.subjectBrainenergymetabolismen
dc.subjectBiabetesmellitusen
dc.subjectTransportadores de ácidos monocarboxílicospt_BR
dc.subjectHighfatdieten
dc.subjectDieta hiperlipidicapt_BR
dc.subjectMCTsen
dc.subjectAGEsen
dc.titleCerebral ketone body oxidation is facilitated by a high fat diet enriched with advanced glycation end products in normal and diabetic ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001099010pt_BR
dc.type.originEstrangeiropt_BR


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