Low-dose adrenocorticotropin test in patients with the acquired immunodeficiency
![Thumbnail](/bitstream/handle/10183/19464/000308874.pdf.jpg?sequence=3&isAllowed=y)
Visualizar/abrir
Data
2001Autor
Tipo
Assunto
Abstract
Adrenocortical insufficiency is a serious complication of AIDS. Usually, integrity of the hypothalamo-pituitary-adrenal (HPA) axis in AIDS patients is assessed by measuring basal cortisol levels and cortisol response to 250 g of ACTH. Recent studies suggest that a lower ACTH dose increases the sensitivity of the procedure. In the present study, we investigated the prevalence of adrenal hypofunction in AIDS patients using a low-dose ACTH test (1 g), evaluated the clinical characteristics that ...
Adrenocortical insufficiency is a serious complication of AIDS. Usually, integrity of the hypothalamo-pituitary-adrenal (HPA) axis in AIDS patients is assessed by measuring basal cortisol levels and cortisol response to 250 g of ACTH. Recent studies suggest that a lower ACTH dose increases the sensitivity of the procedure. In the present study, we investigated the prevalence of adrenal hypofunction in AIDS patients using a low-dose ACTH test (1 g), evaluated the clinical characteristics that might suggest this diagnosis, and the diseases and/or drugs that could be associated with it. We prospectively evaluated 63 very ill AIDS patients and 16 normal controls. A standard examination assessed the presence of signs and symptoms of adrenal insufficiency. Blood samples were collected before and 30 and 40 minutes after an injection of 1 g 1-24 ACTH. No opportunistic disease, signs, symptoms or drugs were associated with an abnormal cortisol response to ACTH. The lowest stimulated cortisol level in the control group was 18.5 g/dL; cortisol levels ≥18 g/dL were taken to indicate a normal HPA axis. Test results revealed that 12/ 63 AIDS patients (19%) had an abnormal HPA axis. With these data in mind, we suggest a prospective adrenal function evaluation of all severely ill AIDS patients. ...
Contido em
The Brazilian journal of infectious diseases. Vol. 5, n. 2 (2001), p. 53-59
Origem
Nacional
Coleções
-
Artigos de Periódicos (39401)Ciências da Saúde (10592)
Este item está licenciado na Creative Commons License
![](/themes/Mirage2Novo//images/lume/cc.png)