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dc.contributor.authorWolff, Fernando Herzpt_BR
dc.contributor.authorNhuch, Claudiopt_BR
dc.contributor.authorStefani, Luciana Paula Cadorept_BR
dc.contributor.authorGlitz, Cristina Lucept_BR
dc.contributor.authorLhullier, Francisco Luiz Rodriguespt_BR
dc.contributor.authorFurlanetto, Tania Weberpt_BR
dc.date.accessioned2010-04-16T09:10:08Zpt_BR
dc.date.issued2001pt_BR
dc.identifier.issn1413-8670pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/19464pt_BR
dc.description.abstractAdrenocortical insufficiency is a serious complication of AIDS. Usually, integrity of the hypothalamo-pituitary-adrenal (HPA) axis in AIDS patients is assessed by measuring basal cortisol levels and cortisol response to 250 g of ACTH. Recent studies suggest that a lower ACTH dose increases the sensitivity of the procedure. In the present study, we investigated the prevalence of adrenal hypofunction in AIDS patients using a low-dose ACTH test (1 g), evaluated the clinical characteristics that might suggest this diagnosis, and the diseases and/or drugs that could be associated with it. We prospectively evaluated 63 very ill AIDS patients and 16 normal controls. A standard examination assessed the presence of signs and symptoms of adrenal insufficiency. Blood samples were collected before and 30 and 40 minutes after an injection of 1 g 1-24 ACTH. No opportunistic disease, signs, symptoms or drugs were associated with an abnormal cortisol response to ACTH. The lowest stimulated cortisol level in the control group was 18.5 g/dL; cortisol levels ≥18 g/dL were taken to indicate a normal HPA axis. Test results revealed that 12/ 63 AIDS patients (19%) had an abnormal HPA axis. With these data in mind, we suggest a prospective adrenal function evaluation of all severely ill AIDS patients.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofThe Brazilian journal of infectious diseases. Vol. 5, n. 2 (2001), p. 53-59pt_BR
dc.rightsOpen Accessen
dc.subjectAIDSen
dc.subjectSíndrome de imunodeficiência adquiridapt_BR
dc.subjectAdrenal insufficiencyen
dc.subjectACTHen
dc.subjectCortisolen
dc.titleLow-dose adrenocorticotropin test in patients with the acquired immunodeficiencypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000308874pt_BR
dc.type.originNacionalpt_BR


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