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dc.contributor.authorAdachi, Lauren Naomi Speziapt_BR
dc.contributor.authorVercelino, Rafaelpt_BR
dc.contributor.authorOliveira, Carla dept_BR
dc.contributor.authorScarabelot, Vanessa Lealpt_BR
dc.contributor.authorSouza, Andressa dept_BR
dc.contributor.authorMedeiros, Liciane Fernandespt_BR
dc.contributor.authorCioato, Stefania Giottipt_BR
dc.contributor.authorCaumo, Wolneipt_BR
dc.contributor.authorTorres, Iraci Lucena da Silvapt_BR
dc.date.accessioned2018-06-27T02:34:01Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn2005-2901pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/179778pt_BR
dc.description.abstractThe present study aimed to determine whether isoflurane interferes with the analgesic effects of acupuncture (Ac) and electroacupuncture (EA), using a neuropathic pain (NP) rat model. In total, 140 male Wistar rats were used; isoflurane-induced nociceptive response was evaluated using the von Frey test, serum calcium-binding protein b (S100b) levels and nerve growth factor (NGF) levels in the left sciatic nerve. The NP model was induced by chronic constriction injury of the sciatic nerve at 14 days after surgery. Treatment was initiated after NP induction with or without isoflurane anesthesia (20 min/ day/8 days). The von Frey test was performed at baseline, 14 days postoperatively, and immediately, 24 h, and 48 h after the last treatment. Results of the nociceptive test and three-way analysis of variance were analyzed by generalized estimating equations, the Bonferroni test, followed by StudenteNewmaneKeuls or Fisher’s least significant difference tests for comparing biochemical parameters (significance defined as p 0.05). At baseline, no difference was noted in the nociceptive response threshold among all groups. Fourteen days after surgery, compared with other groups, NP groups showed a decreased pain threshold, confirming establishment of NP. Ac and EA enhanced the mechanical pain threshold immediately after the last session in the NP groups, without anesthesia. Isoflurane administration caused increased nociceptive threshold in all groups, and this effect persisted for 48 h after the last treatment. There was an interaction between the independent variables: pain, treatments, and anesthesia in serum S100b levels and NGF levels in the left sciatic nerve. Isoflurane enhanced the analgesic effects of Ac and EA and altered serum S100b and left sciatic nerve NGF levels in rats with NP.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofJournal of acupunture and meridian studies. Seoul, Korea (South). Vol. 11, no. 3 (June 2018), p. 97-106pt_BR
dc.rightsOpen Accessen
dc.subjectAcupunturapt_BR
dc.subjectAcupunctureen
dc.subjectElectroacupunctureen
dc.subjectEletroacupunturapt_BR
dc.subjectIsofluraneen
dc.subjectIsofluranopt_BR
dc.subjectNeuralgiapt_BR
dc.subjectNeuropathic painen
dc.titleIsoflurane and the analgesic effect of acupuncture and electroacupuncture in an animal model of neuropathic painpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001070220pt_BR
dc.type.originEstrangeiropt_BR


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