Effects of Achyrocline satureioides inflorescence extracts against pathogenic intestinal bacteria : chemical characterization, in vitro tests, and in vivo evaluation
dc.contributor.author | Moresco, Karla Suzana | pt_BR |
dc.contributor.author | Silveira, Alexandre Kleber | pt_BR |
dc.contributor.author | Zeidán-Chuliá, Fares | pt_BR |
dc.contributor.author | Correa, Ana Paula Folmer | pt_BR |
dc.contributor.author | Oliveira, Rafael Rodrigues de | pt_BR |
dc.contributor.author | Borges, Adriana Giongo | pt_BR |
dc.contributor.author | Grun, Lucas Kich | pt_BR |
dc.contributor.author | Barbé-Tuana, Florencia María | pt_BR |
dc.contributor.author | Zmozinski, Ariane Vanessa | pt_BR |
dc.contributor.author | Brandelli, Adriano | pt_BR |
dc.contributor.author | Vale, Maria Goreti Rodrigues | pt_BR |
dc.contributor.author | Gelain, Daniel Pens | pt_BR |
dc.contributor.author | Bassani, Valquiria Linck | pt_BR |
dc.contributor.author | Moreira, Jose Claudio Fonseca | pt_BR |
dc.date.accessioned | 2018-06-22T02:29:14Z | pt_BR |
dc.date.issued | 2017 | pt_BR |
dc.identifier.issn | 1741-4288 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/179638 | pt_BR |
dc.description.abstract | Three Achyrocline satureioides (AS) inflorescences extracts were characterized: (i) a freeze-dried extract prepared fromthe aqueous extractive solution and (ii) a freeze-dried and (iii) a spray-dried extract prepared from hydroethanol extractive solution (80% ethanol).The chemical profile, antioxidant potential, and antimicrobial activity against intestinal pathogenic bacteria of AS extracts were evaluated. In vitro antioxidant activity was determined by the total reactive antioxidant potential (TRAP) assay. In vivo analysis and characterization of intestinal microbiota were performed in male Wistar rats (saline versus treated animals with AS dried extracts) by high-throughput sequencing analysis: metabarcoding. Antimicrobial activity was tested in vitro by the disc diffusion tests. Moisture content of the extracts ranged from 10 to 15% and 5.7 to 17mg kg−1 of fluorine. AS exhibited antioxidant activity, especially in its freeze-dried form which also exhibited a wide spectrum of antimicrobial activity against intestinal pathogenic bacteria greater than those observed by the antibiotic, amoxicillin, when tested against Bacillus cereus and Staphylococcus aureus. Antioxidant and antimicrobial activities of AS extracts seemed to be positively correlated with the present amount of flavonoids. These findings suggest a potential use of AS as a coadjuvant agent for treating bacterial-induced intestinal diseases with high rates of antibiotic resistance. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Evidence-based complementary and alternative medicine : eCAM. New York. Vol. 2017, ID 2787308, 10 f. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Marcela | pt_BR |
dc.subject | Achyrocline satureioides | pt_BR |
dc.subject | Antioxidantes | pt_BR |
dc.subject | Anti-infecciosos | pt_BR |
dc.title | Effects of Achyrocline satureioides inflorescence extracts against pathogenic intestinal bacteria : chemical characterization, in vitro tests, and in vivo evaluation | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001068168 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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