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dc.contributor.advisorWajner, Simone Magagninpt_BR
dc.contributor.authorLehnen, Tatiana Ederichpt_BR
dc.date.accessioned2018-05-31T02:29:12Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/179052pt_BR
dc.description.abstractNon-thyroidal illness syndrome (NTIS) is characterized by changes in the metabolism of thyroid hormones (TH), regulated by enzymes called iodothyronine deiodinases (type 1, 2 and 3). Alterations on the function of deiodinases has been observed in several diseases, mainly in the cardiovascular diseases, being generally observed in patients with myocardial infarction (MI). These alterations leads to an inverse correlation of low T3 levels with poor prognosis and mortality. However, the mechanisms of this syndrome are still poorly understood. Thus, given the importance of TH metabolism in cardiovascular diseases, mechanisms involving the pathogenesis of NTIS are studied in vivo and in vitro models, and due to several lacks in the understanding of the pathophysiological mechanisms of NTIS, there is no currently approved treatment for these set of TH derangements.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoporpt_BR
dc.rightsOpen Accessen
dc.subjectDoenças cardiovascularespt_BR
dc.subjectSíndromes do eutireóideo-doentept_BR
dc.subjectAcetilcisteínapt_BR
dc.subjectEstresse oxidativopt_BR
dc.subjectHormônios tireóideospt_BR
dc.titleEfeito da N-acetilcisteína sobre o metabolismo dos hormônios tireoidianos, função cardíaca e estresse oxidativo em modelo animal de síndrome do T3 baixopt_BR
dc.typeTesept_BR
dc.contributor.advisor-coMaia, Ana Luiza Silvapt_BR
dc.identifier.nrb001053540pt_BR
dc.degree.grantorUniversidade Federal do Rio Grande do Sulpt_BR
dc.degree.departmentFaculdade de Medicinapt_BR
dc.degree.programPrograma de Pós-Graduação em Ciências Médicas: Endocrinologiapt_BR
dc.degree.localPorto Alegre, BR-RSpt_BR
dc.degree.date2017pt_BR
dc.degree.leveldoutoradopt_BR


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