Efeito da N-acetilcisteína sobre o metabolismo dos hormônios tireoidianos, função cardíaca e estresse oxidativo em modelo animal de síndrome do T3 baixo

Abstract

Non-thyroidal illness syndrome (NTIS) is characterized by changes in the metabolism of thyroid hormones (TH), regulated by enzymes called iodothyronine deiodinases (type 1, 2 and 3). Alterations on the function of deiodinases has been observed in several diseases, mainly in the cardiovascular diseases, being generally observed in patients with myocardial infarction (MI). These alterations leads to an inverse correlation of low T3 levels with poor prognosis and mortality. However, the mechanisms of this syndrome are still poorly understood. Thus, given the importance of TH metabolism in cardiovascular diseases, mechanisms involving the pathogenesis of NTIS are studied in vivo and in vitro models, and due to several lacks in the understanding of the pathophysiological mechanisms of NTIS, there is no currently approved treatment for these set of TH derangements.