Mostrar registro simples

dc.contributor.authorCorsetti, Adrianapt_BR
dc.contributor.authorBahuschewskyj, Claudiapt_BR
dc.contributor.authorPonzoni, Deisept_BR
dc.contributor.authorLangie, Renan Cavalheiropt_BR
dc.contributor.authorSantos, Luis Alberto dospt_BR
dc.contributor.authorCamassola, Melissapt_BR
dc.contributor.authorNardi, Nance Beyerpt_BR
dc.contributor.authorPuricelli, Edelapt_BR
dc.date.accessioned2017-07-13T02:37:00Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.issn1678-7757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/163933pt_BR
dc.description.abstractObjectives: this study aimed to evaluate the potential of adupose-derived stem cells (ASCs) combined witha modified tricalcium phospate (a-TCP) or gelatin sponge (GS) scaffolds for bone healing in a rat model. Material and Methods: Bone defects were surgically created in the femur of adult SHR rats and filled with the scaffolds, empty or combined with ASCs. The results were analyzed by histology abd histomorphometry on days seven, 13, 30 and 60. Results: Significantly increased bone repair was observed on days seven and 60 in animals treated with a-TCP/ASCs, and on day 14 in the group trated with GS/ASCs, when compared with the groups treated with the biomaterials alone. Intenses fibroplastia was observed in the group trated with GS alone, on days 14 and 30. Conclusions: Our results showed that the use of ascs combined with a-TCP scaffold suggests osteocunductive property that results in a biological support to the cells, whereas the GS scaffold functions just as a carrier. These results confirm the potential os ASCs in accelerating bone repais in in vivo experimental rat models. These results suggest a new alternative for treating bone defects.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofJournal of applied oral science. Bauru. Vol. 25, no. 1 (Jan./Feb. 2017), p. 10-19pt_BR
dc.rightsOpen Accessen
dc.subjectRegeneração ósseapt_BR
dc.subjectBone regenerationen
dc.subjectCalcium cementen
dc.subjectCélulas-troncopt_BR
dc.subjectCálciopt_BR
dc.subjectAdipose-derived stem cellsen
dc.subjectRat modelen
dc.titleRepair of bone defects using adipose-derived stem cells combined with alpha-tricalcium phosphate and gelatin sponge scaffolds in a rat modelpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001023559pt_BR
dc.type.originNacionalpt_BR


Thumbnail
   

Este item está licenciado na Creative Commons License

Mostrar registro simples