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dc.contributor.authorOliveira, Angélica Salatino dept_BR
dc.contributor.authorMurray, Josephpt_BR
dc.contributor.authorKieling, Christian Costapt_BR
dc.contributor.authorGenro, Júlia Pasqualinipt_BR
dc.contributor.authorSilva, Luciana Anselmi Duarte dapt_BR
dc.contributor.authorWehrmeister, Fernando Césarpt_BR
dc.contributor.authorBarros, Fernando Celso Lopes Fernandes dept_BR
dc.contributor.authorMenezes, Ana Maria Baptistapt_BR
dc.contributor.authorRohde, Luis Augusto Paimpt_BR
dc.contributor.authorHutz, Mara Helenapt_BR
dc.date.accessioned2017-06-08T02:31:58Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/159388pt_BR
dc.description.abstractConduct problems in childhood and adolescence are significant precursors of crime and violence in young adulthood. The purpose of the current study is to test the interaction between prenatal maternal smoking and COMT Val158Met in conduct problems and crime in the 1993 Pelotas Birth Cohort Study. Conduct problems were assessed through the parent version of the Strengths and Difficulties Questionnaire at ages 11 and 15 years. A translated version of a confidential self-report questionnaire was used to collect criminal data at 18 years of age. Negative binomial regression analyses showed an association between prenatal maternal smoking and SDQ conduct problem scores (IRR = 1.24; 95% CI: 1.14–1.34; p < 0.001) at 11 years of age. However, no evidence was found for an association between COMT genotypes and conduct scores or for an interaction between maternal smoking and this gene in predicting conduct problems. Very similar results were obtained using the 15 years conduct scores and crime measure at age 18. Prenatal maternal smoking was associated with crime (IRR = 1.28; 95% CI: 1.09–1.48; p = 0.002) but neither COMT genotypes nor the possible interaction between gene and maternal smoking were significantly associated with crime. Replications of GxE findings across different social contexts are critical for testing the robustness of findings.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofScientific reports. London. Vol. 6 (2016), 29900, 6 p.pt_BR
dc.rightsOpen Accessen
dc.subjectTranstorno do déficit de atenção com hiperatividadept_BR
dc.subjectGravidezpt_BR
dc.titleCOMT and prenatal maternal smoking in associations with conduct problems and crime : the Pelotas 1993 birth cohort studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001016292pt_BR
dc.type.originEstrangeiropt_BR


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