Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalis

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2015Author
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Abstract
Introduction: Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome. Methods: Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin. Results: A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro. Conclusions: Subinhibitory concentrations of vancomyci ...
Introduction: Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome. Methods: Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin. Results: A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro. Conclusions: Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains. ...
In
Revista da Sociedade Brasileira de Medicina Tropical. Vol. 48, n. 5 (set./out. 2015), p. 617-621
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National
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