Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population
dc.contributor.author | Biolchi, Vanderlei | pt_BR |
dc.contributor.author | Silva Neto, Brasil | pt_BR |
dc.contributor.author | Koff, Walter Jose | pt_BR |
dc.contributor.author | Brum, Ilma Simoni | pt_BR |
dc.date.accessioned | 2015-07-11T02:00:17Z | pt_BR |
dc.date.issued | 2012 | pt_BR |
dc.identifier.issn | 1677-6119 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/119119 | pt_BR |
dc.description.abstract | Benign prostatic hyperplasia (BPH) is a very frequent age-related proliferative abnormality in men. Polymorphic CAG repeat in the androgen receptor (AR) can alter transactivation of androgen-responsive genes and potentially infl uence BPH risk. We investigated the association between CAG repeat length and risk of BPH in a case-control study of a Brazilian population. We evaluated 214 patients; 126 with BPH and 88 healthy controls. DNA was extracted from peripheral leucocytes and the AR gene was analyzed using fragment analysis. Hazard ratio (HR) and 95% confi dence interval were estimated using logistic regression models. Mean CAG length was not different between patients with BPH and controls. The CAG repeat length was examined as a categorical variable (CAG ≤ 21 vs. CAG > 21 and CAG ≤ 22 vs. CAG > 22) and did not differ between the control vs. the BPH group. We found no evidence for an association between AR CAG repeat length in BPH risk in a population-based sample of Brazilians | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | International brazilian journal of urology. Rio de Janeiro, RJ. Vol. 38, no. 3 (May/June 2012), p. 373-379 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Receptores androgênicos | pt_BR |
dc.subject | Polimorfismo genético | pt_BR |
dc.subject | Hiperplasia prostática | pt_BR |
dc.title | Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000964015 | pt_BR |
dc.type.origin | Nacional | pt_BR |
Este item está licenciado na Creative Commons License
-
Artigos de Periódicos (39552)Ciências da Saúde (10602)
-
Artigos de Periódicos (39552)Ciências Biológicas (3081)