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dc.contributor.authorPereira, Gabriela Garrastazupt_BR
dc.contributor.authorDimer, Frantiescoli Anversapt_BR
dc.contributor.authorGuterres, Silvia Stanisçuaskipt_BR
dc.contributor.authorKechinski, Carolina Pereirapt_BR
dc.contributor.authorGranada, Jonas Eichelbergerpt_BR
dc.contributor.authorCardozo, Nilo Sérgio Medeirospt_BR
dc.date.accessioned2015-04-11T02:01:06Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn0100-4042pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/115203pt_BR
dc.description.abstractThe influence of the composition and preparation method on the sol–gel transition temperature (Tsol–gel) and rheological response of poloxamer-based formulations was determined. Manual and more complex mechanical stirring were found to provide similar results. In addition, a linear dependence of Tsol–gel on the poloxamer content was observed in the range of concentrations analyzed, and a Poloxamer 407® concentration of 18% was selected. The addition of hyaluronic acid did not lead to significant changes in the Tsol–gel values. In contrast, the addition of microparticles caused a reduction in Tsol–gel without a significant reduction in gel strength, and pseudoplastic characteristics were observed, indicating that a thermoreversible gel was obtained with a rheology suitable for application in the treatment of burn wounds.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofQuímica nova. São Paulo. Vol. 36, n. 8 (2013), p. 1121-1125pt_BR
dc.rightsOpen Accessen
dc.subjectThermoreversible gelen
dc.subjectCopolímerospt_BR
dc.subjectRheologyen
dc.subjectReologiapt_BR
dc.subjectBurn woundsen
dc.titleFormulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acidpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000956086pt_BR
dc.type.originNacionalpt_BR


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