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dc.contributor.authorZanette, Simone de Azevedopt_BR
dc.contributor.authorSarria, Jairo Alberto Dussánpt_BR
dc.contributor.authorSouza, Andressa dept_BR
dc.contributor.authorDeitos, Alíciapt_BR
dc.contributor.authorTorres, Iraci Lucena da Silvapt_BR
dc.contributor.authorCaumo, Wolneipt_BR
dc.date.accessioned2015-02-14T02:19:07Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn1744-8069pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/110152pt_BR
dc.description.abstractBackground: Fibromyalgia (FM) is conceptualized as a central sensitization (CS) condition, that presents high serum brain-derived neurotrophic factor (BDNF) and neuroglia activation. Although the S100B protein regulates neuroglia functions, it has been traditionally used as a proxy of central nervous system damage. However, neither BDNF nor S100B association with the clinical picture of FM has been elucidated. To explore their association with the pressure-pain threshold (PPT) in FM, we performed a cross-sectional study, including 56 females with confirmed FM aged 18–65 years. Linear regression models were used to adjust for potential confounding factors between serum BDNF, S100B and PPT. Results: Serum BDNF and S100B were correlated (Spearman’s Rho = 0.29). Serum BDNF (log) and S100B (log) were correlated with the PPT (log) (Partial η2 = 0.129, P = 0.012 for the BDNF (log), and Partial η2 = 0.105, P = 0.025 for the S100B (log)). Serum BDNF (log) was inversely associated with PPT (log) (β = −1.01, SE = 0.41), age (β = −0.02, SE = 0.15) and obsessive compulsive disorder (β = −0.36, SE = 0.15), while serum S100B (log) was inversely associated with PPT (log) (β = −1.38, SE = 0.50), only. Conclusions: Both neuroglia key mediators in the CS process were inversely correlated with the PPT. Serum assessment of BDNF and S100B deserve further study to determine its potential as a proxy for the CS spectrum in FM.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofMolecular pain. [London]. Vol. 10 (8 Jul. 2014), p. 46, 9 p.pt_BR
dc.rightsOpen Accessen
dc.subjectFibromialgiapt_BR
dc.subjectFibromyalgiaen
dc.subjectProteínas S100pt_BR
dc.subjectS100Ben
dc.subjectBDNFen
dc.subjectFator neurotrófico derivado do encéfalopt_BR
dc.subjectLimiar da dorpt_BR
dc.subjectPain-pressure thresholden
dc.subjectCentral sensitizationen
dc.titleHigher serum S100b and BDNF levels are correlated with a lower pressure-pain threshold in fibromyalgiapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000929928pt_BR
dc.type.originEstrangeiropt_BR


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