Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil
dc.contributor.author | Bajerski, Lisiane | pt_BR |
dc.contributor.author | Paim, Clésio Soldateli | pt_BR |
dc.contributor.author | Pereira, Andréa Garcia | pt_BR |
dc.contributor.author | Dias, Carolina Lupi | pt_BR |
dc.contributor.author | Rossi, Rochele Cassanta | pt_BR |
dc.contributor.author | Todeschini, Vítor | pt_BR |
dc.contributor.author | Steppe, Martin | pt_BR |
dc.contributor.author | Bergold, Ana Maria | pt_BR |
dc.contributor.author | Froehlich, Pedro Eduardo | pt_BR |
dc.date.accessioned | 2013-07-03T01:43:53Z | pt_BR |
dc.date.issued | 2013 | pt_BR |
dc.identifier.issn | 0100-4042 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/73025 | pt_BR |
dc.description.abstract | A stability-indicating method using MEKC was validated for the analysis of olmesartan medoxomil in tablets. Successful separation was achieved using a fused silica capillary (40 cm x 50 μm i.d.); background electrolyte consisted of a combination of 10 mmol L-1 borate buffer and 5 mmol L-1 anionic detergent sodium dodecyl sulfate (95:5; v/v) pH 6.5; hydrodynamic mode at 50 mBar for 5 s; 25 kV separation voltage at 25 ºC; and column temperature 25 ºC with detection at 257 nm. The proposed method, validated following ICH guidelines, was applied to the determination of this antihypertensive with good results compared with an LC method. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Química nova. São Paulo: Sociedade Brasileira de Química, 1978-. Vol. 36, n. 1, (2013), p. 34-39 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Olmesartan medoxomil | en |
dc.subject | Cromatografia capilar eletrocinética micelar | pt_BR |
dc.subject | MEKC | en |
dc.subject | Cromatografia liquida | pt_BR |
dc.subject | Olmesartana medoxomila | pt_BR |
dc.subject | LC | en |
dc.title | Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000881771 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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