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Esquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinal

dc.contributor.authorMenegatti, Ricardopt_BR
dc.contributor.authorFraga, Carlos Alberto Manssourpt_BR
dc.contributor.authorBarreiro, Eliezer J.pt_BR
dc.contributor.authorEifler-Lima, Vera Luciapt_BR
dc.contributor.authorRates, Stela Maris Kuzept_BR
dc.contributor.authorDalla Costa, Teresa Cristina Tavarespt_BR
dc.date.accessioned2013-07-03T01:42:46Zpt_BR
dc.date.issued2004pt_BR
dc.identifier.issn0100-4042pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/72986pt_BR
dc.description.abstractSchizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry point of view all different classes of antipsychotic drugs, emphasizing the rational design, structure activity relationships (SAR) and physico-chemical properties related with its molecular mechanism of action.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoporpt_BR
dc.relation.ispartofQuímica nova. Vol. 27, n. 3 (2004), p. 447-455pt_BR
dc.rightsOpen Accessen
dc.subjectSchizophreniaen
dc.subjectEsquizofreniapt_BR
dc.subjectAntipsicóticospt_BR
dc.subjectAntipsychotic drugsen
dc.subjectDopamine receptor ligandsen
dc.subjectReceptores dopaminérgicospt_BR
dc.titleEsquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinalpt_BR
dc.title.alternativeSchizophrenia : forty years of the dopaminergic hypothesis from the medicinal chemistry point of viewen
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000419540pt_BR
dc.type.originNacionalpt_BR


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