Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico : preparação em etapa única e caracterização biofarmacêutica
dc.contributor.author | Domingues, Gislane Scholze | pt_BR |
dc.contributor.author | Guterres, Silvia Stanisçuaski | pt_BR |
dc.contributor.author | Beck, Ruy Carlos Ruver | pt_BR |
dc.contributor.author | Pohlmann, Adriana Raffin | pt_BR |
dc.date.accessioned | 2013-07-02T01:43:16Z | pt_BR |
dc.date.issued | 2008 | pt_BR |
dc.identifier.issn | 0100-4042 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/72871 | pt_BR |
dc.description.abstract | The aim of this work was to prepare and characterize spray-dried nanocapsule-coated microparticles obtained in one step, using indomethacin as a hydrophobic drug model and poly(ε-caprolactone) or Eudragit® RS100, as polymers. Nanocapsule-coated microparticles showed micrometric mean sizes (10 - 15 µm) and a reduced surface area (75 – 85 m2g-1) compared to the raw material (214 m2g-1). Microparticles coated with Eudragit® RS100-nanocapsules showed a better control of the drug release. The release profiles fit to the monoexponetial model and to the Power Law. The mechanism of the indomethacin release from the microparticles is non-Fickian and depends on the particles desagglomeration. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | por | pt_BR |
dc.relation.ispartof | Química nova. São Paulo. Vol. 31, n. 8, (out. 2008), p. 1966-1972 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Indomethacin | en |
dc.subject | Microparticulas | pt_BR |
dc.subject | Nanocápsulas | pt_BR |
dc.subject | Microparticles | en |
dc.subject | Nanocapsules | en |
dc.subject | Indometacina | pt_BR |
dc.title | Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico : preparação em etapa única e caracterização biofarmacêutica | pt_BR |
dc.title.alternative | Nanocapsule-coated microparticles prepared in one step : characterization and in vitro drug release profiles evaluation | en |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000676821 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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