Adsorção de oligonucleotídeos em nanoemulsões obtidas por emulsificação espontânea
dc.contributor.author | Martini, Érico | pt_BR |
dc.contributor.author | Carvalho, Edison Luis Santana | pt_BR |
dc.contributor.author | Teixeira, Helder Ferreira | pt_BR |
dc.contributor.author | Leão, Fabiana | pt_BR |
dc.contributor.author | Oliveira, Mônica Cristina de | pt_BR |
dc.date.accessioned | 2013-07-02T01:43:15Z | pt_BR |
dc.date.issued | 2007 | pt_BR |
dc.identifier.issn | 0100-4042 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/72868 | pt_BR |
dc.description.abstract | This paper describes the adsorption of an oligothymidylate (pdT16) on nanoemulsions obtained by spontaneous emulsification procedures. Formulations were composed by medium chain triglycerides, egg lecithin, glycerol, water (NE) and stearylamine (NESA). After optimization of operating conditions, the mean droplet size was smaller than 255 nm. Adsorption isotherms showed a higher amount of pdT16 adsorbed on cationic NESA (60 mg/g) compared to NE (20 mg/g). pdT16 adsorption was also evidenced by the inversion of the ζ-potential of NESA (from +50 to -30 mV) and the morphology of oil droplets examined through transmission electron microscopy. The overall results showed the role of electrostatic interactions on the adsorption of pdT16 on the oil/water interface of nanoemulsions. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | por | pt_BR |
dc.relation.ispartof | Química nova. Vol. 30, n. 4 (July/Aug. 2007), p. 930-934 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Oligonucleotídeos | pt_BR |
dc.subject | Cationic nanoemulsions | en |
dc.subject | Nanoemulsões | pt_BR |
dc.subject | Oligonucleotides | en |
dc.subject | Adsorption | en |
dc.title | Adsorção de oligonucleotídeos em nanoemulsões obtidas por emulsificação espontânea | pt_BR |
dc.title.alternative | Oligonucleotide adsorption on nanoemulsions obtained by spontaneous emulsification | en |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000646250 | pt_BR |
dc.type.origin | Nacional | pt_BR |
Este item está licenciado na Creative Commons License
-
Artigos de Periódicos (40021)Ciências da Saúde (10691)