Insulin therapy does not interfere with venous endothelial function evaluation in patients with type 2 diabetes mellitus
dc.contributor.author | Silva, Antônio Marcos Vargas da | pt_BR |
dc.contributor.author | Penno, Luciana de Moraes | pt_BR |
dc.contributor.author | Bertoluci, Marcello Casaccia | pt_BR |
dc.contributor.author | Irigoyen, Maria Claudia Costa | pt_BR |
dc.contributor.author | Schaan, Beatriz D'Agord | pt_BR |
dc.date.accessioned | 2012-06-27T01:32:04Z | pt_BR |
dc.date.issued | 2010 | pt_BR |
dc.identifier.issn | 1807-5932 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/49795 | pt_BR |
dc.description.abstract | INTRODUCTION: Endothelium-dependent dilation is improved in insulin-treated diabetic patients, but this effect is probably due to improved glycemic control. The objective of the present study was to compare endotheliumdependent dilation in patients with well-controlled type 2 diabetes who are or are not using insulin as part of their therapy. METHODS: We studied 27 patients with type 2 diabetes (11 women, 60.3 years ¡ 6 years, with HbA1c , 7% and no nephropathy), including 16 patients treated with anti-diabetic agents (No-Ins, 8 women) and 11 patients treated with insulin alone or in combination with anti-diabetic agents (Ins, 3 women). Endothelial function was evaluated by the dorsal hand vein technique, which measures changes in vein diameter in response to phenylephrine, acetylcholine (endothelium-dependent vasodilation) and sodium nitroprusside (endothelium-independent vasodilation). RESULTS: Age, systolic blood pressure (No-Ins: 129.4 mmHg ¡ 11.8 mmHg, Ins: 134.8 mmHg ¡ 12.0 mmHg; P = 0.257), HbA1c, lipids and urinary albumin excretion rate [No-Ins: 9 mg/24 h (0-14.1 mg/24 h) vs. Ins: 10.6 mg/24 h (7.5- 14.4 mg/24 h), P = 0.398] were similar between groups. There was no difference between endothelium-dependent vasodilation of the No-Ins group (59.3% ¡ 26.5%) vs. the Ins group (54.0% ¡ 16.3%; P = 0.526). Endotheliumindependent vasodilation was also similar between the No-Ins (113.7% ¡ 35.3%) and Ins groups (111.9% ¡ 28.5%; P = 0.888). CONCLUSIONS: Subcutaneous insulin therapy does not interfere with venous endothelial function in type 2 diabetes when glycemic and blood pressure control are stable. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Clinics. Sao Paulo. Vol. 65, no. 11 (2010), p. 1139-1142 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Diabetes mellitus, type 2 | en |
dc.subject | Diabetes mellitus tipo 2 | pt_BR |
dc.subject | Complicações do diabetes | pt_BR |
dc.subject | Diabetes complications | en |
dc.subject | Vascular diseases | en |
dc.subject | Doenças vasculares | pt_BR |
dc.subject | Endotélio vascular | pt_BR |
dc.subject | Vascular endothelium | en |
dc.subject | Insulina | pt_BR |
dc.subject | Insulin | en |
dc.title | Insulin therapy does not interfere with venous endothelial function evaluation in patients with type 2 diabetes mellitus | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000778660 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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