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dc.contributor.authorCheinquer, Nelsonpt_BR
dc.contributor.authorCheinquer, Hugopt_BR
dc.contributor.authorWolff, Fernando Herzpt_BR
dc.contributor.authorCoelho-Borges, Silviapt_BR
dc.date.accessioned2012-03-23T01:20:56Zpt_BR
dc.date.issued2010pt_BR
dc.identifier.issn1413-8670pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/37822pt_BR
dc.description.abstractBackground and objectives: Evidence suggests that sustained virologic response to interferon treatment decreases incidence of hepatocellular carcinoma in patients with hepatitis C virus cirrhosis. This study was designed to compare the incidence of hepatocellular carcinoma among cirrhotic patients exposed to interferon based treatment with or without achieving a sustained virological response, in order to evaluate the role of interferon itself in the prevention hepatocellular carcinoma. Methods: A cohort of 85 patients with compensated hepatitis C cirrhosis was followed after treatment with interferon and ribavirin. Sustained virological response was defi ned as negative polymerase chain reaction assay 24 weeks after the end of treatment. Patients were followed every 6 months with ultrasound and alpha-fetoprotein. Hepatocellular carcinoma was diagnosed by the fi nding of a focal liver lesion greater than 2 cm with arterial hypervascularization on two imaging techniques and/or by liver biopsy. Results: The mean follow-up time was 32.1 ± 20 months for patients who achieved a sustained virological response and 28.2 ± 18 months among 47 patients (55%) without SVR. Hepatocellular carcinoma was diagnosed in 1 (3%) vs. 8 (17%) responders and non responders respectively (p = 0.02). Conclusion: Patients with cirrhosis due to hepatitis C virus who achieved sustained virological response had signifi cantly lower incidence of hepatocellular carcinoma when compared to those without treatment response. Interferon treatment without achieving sustained virological response does not seem to protect against hepatocellular carcinoma.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofThe Brazilian journal of infectious diseases. Vol. 14, n. 5 (set./out. 2010), p. 457-461pt_BR
dc.rightsOpen Accessen
dc.subjectHepatocellular carcinomaen
dc.subjectCarcinoma hepatocelularpt_BR
dc.subjectCirrose hepáticapt_BR
dc.subjectHCV interferonen
dc.subjectHepatite Cpt_BR
dc.subjectSustained virologic responseen
dc.subjectCirrhosisen
dc.titleEffect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosispt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000778485pt_BR
dc.type.originNacionalpt_BR


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