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dc.contributor.authorXavier, Melissa Orzechowskipt_BR
dc.contributor.authorPasqualotto, Alessandro Comarupt_BR
dc.contributor.authorAquino, Valério Rodriguespt_BR
dc.contributor.authorSukiennik, Teresa Cristina Teixeirapt_BR
dc.contributor.authorSevero, Luiz Carlospt_BR
dc.date.accessioned2012-03-23T01:20:44Zpt_BR
dc.date.issued2009pt_BR
dc.identifier.issn1413-8670pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/37798pt_BR
dc.description.abstractPiperacillin-tazobactam is a broad spectrum antimicrobial agent that can cause false-positive results in the commercial Platelia Aspergillus EIA test. So far, no study has been performed in Latin America to evaluate the clinical implication of this finding. Here we studied the potential for galactomannan detection in piperacillintazobactam batches commercialized in the Brazilian market. Five batches from distinct laboratories were tested in duplicate in the Platelia Aspergillus EIA according to the manufacturer’s instructions. Only one drug showed crossreaction at a cut-off of 0.5. Human serum was spiked with this particular drug aiming to mimic achievable piperacillintazobactam concentrations in the serum. Results were all negative for galactomannan detection, even at high drug concentrations. Results from this pilot study suggest that piperacillin-tazobactam might not be a clinically significant cause of false-positive results in the Platelia Aspergillus EIA test in Brazil.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofThe Brazilian journal of infectious diseases. Vol. 13, no. 5 (out. 2009), p. 353-355pt_BR
dc.rightsOpen Accessen
dc.subjectAgentes antibacterianospt_BR
dc.subjectPiperacillin-tazobactamen
dc.subjectAspergilluspt_BR
dc.subjectAspergillosisen
dc.subjectTécnicas imunoenzimáticaspt_BR
dc.subjectPlatelia Aspergillusen
dc.subjectMananaspt_BR
dc.subjectGalactomannanen
dc.subjectReações falso-positivaspt_BR
dc.subjectÁcido penicilânicopt_BR
dc.subjectQuimicapt_BR
dc.subjectAlergia e imunologiapt_BR
dc.subjectAnálisept_BR
dc.subjectAnálogo e derivadospt_BR
dc.subjectPiperacilinapt_BR
dc.titleGalactomannan detection from piperacillin-tazobactam brands available in the Brazilian marketpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000751380pt_BR
dc.type.originNacionalpt_BR


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