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dc.contributor.authorGuedes Pinto, Thiagopt_BR
dc.contributor.authorViana, Milena De Barrospt_BR
dc.contributor.authorCury, Patrícia Ramospt_BR
dc.contributor.authorMartins, Manoela Dominguespt_BR
dc.contributor.authorSantos, Jean Nunes dospt_BR
dc.contributor.authorRibeiro, Daniel Arakipt_BR
dc.date.accessioned2024-01-26T04:47:54Zpt_BR
dc.date.issued2023pt_BR
dc.identifier.issn1873-149Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/271179pt_BR
dc.description.abstractThe aim of this systematic review was to answer the question of whether crack cocaine can induce cellular and molecular alterations and whether such alterations are somehow related to clinical lesions in the oral mucosa. The searches were undertaken in three electronic databases and conducted based on the PRISMA 2020 statement. Eleven studies published between 1994 and 2020 were analyzed. The quality of the included studies was assessed by two independent reviewers (TGP and DAR) through a confounder’s categorization methodology, in which final ratings were attributed (strong, moderate or weak) for each study. From 11 studies included, 7 evaluated the cellular/molecular impact of the addiction in a total of 492 individuals and compared to a control (non-exposure) group (n = 472). The main tests used for cellular alteration were MN and AgNORs. Cells from crack cocaine groups exhibited increased proliferation and MN counting. Only four studies evaluated the prevalence of oral lesions. All of them showed that individuals exposed to crack cocaine presented an increased number of oral lesions. Most studies showed good quality. In conclusion, our results demonstrate that crack use may induce changes at the cellular and molecular level and also exhibit an increased number of oral lesions. However, a correlation between such changes and oral mucosa lesions still needs further investigation and elucidation through other clinical studies in humans.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPathophysiology : the official journal of the International Society for Pathophysiology. Amsterdam. Vol. 30, n. 4 (2023), p. 630-639pt_BR
dc.rightsOpen Accessen
dc.subjectCrack cocaineen
dc.subjectCocaína crackpt_BR
dc.subjectDNA damageen
dc.subjectDano ao DNApt_BR
dc.subjectGenotoxicityen
dc.subjectGenotoxicidadept_BR
dc.subjectOral mucosal lesionsen
dc.titleAre cytomorphogenetic events correlated with oral mucosal lesions induced by crack cocaine use? A systematic reviewpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001195051pt_BR
dc.type.originEstrangeiropt_BR


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