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dc.contributor.authorCastro Filho, João Batista Saldanha dept_BR
dc.contributor.authorPompeo, Jeferson de Castropt_BR
dc.contributor.authorMachado, Rafael Berlezipt_BR
dc.contributor.authorGonçalves, Luiz Felipe Santospt_BR
dc.contributor.authorBauer, Andrea Carlapt_BR
dc.contributor.authorManfro, Roberto Cerattipt_BR
dc.date.accessioned2023-11-17T03:22:31Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn1432-2277pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/267163pt_BR
dc.description.abstractDelayed graft function (DGF) is a common complication of kidney transplantation and frequently leads to the necessity of surveillance biopsies. The purpose of this study is to describe the histological findings in surveillance biopsies of deceased donor kidney transplant recipients and evaluate the risk factors for graft outcomes. This is a monocentric, retrospective study including kidney transplant recipients that underwent a graft biopsy during the DGF period between January 2006 and July 2019. 356 biopsies were performed in 335 deceased donor transplant recipients. Biopsies were analyzed according to the Banff classification. The main histological findings were: acute tubular necrosis in 150 biopsies (42.1%), acute rejection in 96 biopsies (26.9%), and borderline findings in 91 biopsies (25.5%). In the multivariate analysis, recipient age (p = 0.028) and DGF duration (p = 0.005) were associated with rejection, antibody-induction with anti-thymocyte globulin (ATG) was protective (p = 0.001). The occurrence of rejection was associated with lower death-censored graft survival (log-rank; p = 0.009). Surveillance biopsies of kidney grafts experiencing DGF remain an essential tool for the care of kidney transplant recipients. The recipient’s age and duration of DGF are independent risk factors for acute rejection, while antibody-induction therapy with ATG is associated with protection from its occurrence.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofTransplant international. Heidelberg, FRG. Vol. 35 (Mar. 2022), 10344, 10 p.pt_BR
dc.rightsOpen Accessen
dc.subjectTransplante de rimpt_BR
dc.subjectRenal transplantationen
dc.subjectDelayed graft functionen
dc.subjectFunção retardada do enxertopt_BR
dc.subjectRenal biopsyen
dc.subjectBiópsiapt_BR
dc.subjectRejeição de enxertopt_BR
dc.subjectAcute rejectionen
dc.subjectTolerância imunológicapt_BR
dc.subjectImmunosuppressionen
dc.titleDelayed graft function under the microscope : surveillance biopsies in kidney transplantationpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001177179pt_BR
dc.type.originEstrangeiropt_BR


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