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dc.contributor.authorGuedes, Marina Delanni Vitóriapt_BR
dc.contributor.authorMarques, Morgana Souzapt_BR
dc.contributor.authorBerlitz, Simone Jacobuspt_BR
dc.contributor.authorFacure, Murilo Henrique Moreirapt_BR
dc.contributor.authorCorrêa, Daniel Souzapt_BR
dc.contributor.authorSteffens, Claricept_BR
dc.contributor.authorContri, Renata Vidorpt_BR
dc.contributor.authorKülkamp-Guerreiro, Irene Clemespt_BR
dc.date.accessioned2023-09-13T03:32:20Zpt_BR
dc.date.issued2023pt_BR
dc.identifier.issn2079-4991pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/264905pt_BR
dc.description.abstractHere, we report on the development of lipid-based nanostructures containing zidovudine (1 mg/mL) and lamivudine (0.5 mg/mL) for oral administration in the pediatric population, eliminating the use of organic solvents, which is in accordance with green chemistry principles. The formulations were obtained by ultrasonication using monoolein (MN) or phytantriol (PN), which presented narrow size distributions with similar mean particle sizes (~150 nm) determined by laser diffraction. The zeta potential and the pH values of the formulations were around 􀀀4.0 mV and 6.0, respectively. MN presented a slightly higher incorporation rate compared to PN. Nanoemulsions were obtained when using monoolein, while cubosomes were obtained when using phytantriol, as confirmed by Small-Angle X-ray Scattering. The formulations enabled drug release control and protection against acid degradation. The drug incorporation was effective and the analyses using an electronic tongue indicated a difference in palatability between the nanotechnological samples in comparison with the drug solutions. In conclusion, PN was considered to have the strongest potential as a novel oral formulation for pediatric HIV treatment.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofNanomaterials. Basel. Vol. 13, n. 4 (2023), 770, 18 p.pt_BR
dc.rightsOpen Accessen
dc.subjectQuímica verdept_BR
dc.subjectChildrenen
dc.subjectCubosomesen
dc.subjectNanoestruturaspt_BR
dc.subjectGreen chemistryen
dc.subjectAdministração oralpt_BR
dc.subjectNanoemulsionen
dc.subjectLiberação controlada de fármacospt_BR
dc.subjectHIVpt_BR
dc.subjectOral administrationen
dc.subjectSaúde da criançapt_BR
dc.subjectLipídeospt_BR
dc.titleLamivudine and zidovudine-loaded nanostructures : green chemistry preparation for pediatric oral administrationpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001176301pt_BR
dc.type.originEstrangeiropt_BR


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