Non-thyroidal illness syndrome predicts outcome in adult critically ill patients : a systematic review and meta-analysis
dc.contributor.author | Vidart, Josi | pt_BR |
dc.contributor.author | Jaskulski, Paula da Rocha | pt_BR |
dc.contributor.author | Kunzler, Ana Laura Fischer | pt_BR |
dc.contributor.author | Marschner, Rafael Aguiar | pt_BR |
dc.contributor.author | Silva, André Ferreira de Azeredo da | pt_BR |
dc.contributor.author | Wajner, Simone Magagnin | pt_BR |
dc.date.accessioned | 2023-06-21T03:33:23Z | pt_BR |
dc.date.issued | 2022 | pt_BR |
dc.identifier.issn | 2049-3614 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/259264 | pt_BR |
dc.description.abstract | We performed a systematic review and meta-analysis to comprehensively determine the prevalence and the prognostic role of non-thyroidal illness syndrome (NTIS) in critically ill patients. We included studies that assessed thyroid function by measuring the serum thyroid hormone (TH) level and in-hospital mortality in adult septic patients. Reviews, case reports, editorials, letters, animal studies, duplicate studies, and studies with irrelevant populations and inappropriate controls were excluded. A total of 6869 patients from 25 studies were included. The median prevalence rate of NTIS was 58% (IQR 33.2-63.7). In univariate analysis, triiodothyronine (T3) and free T3 (FT3) levels in non-survivors were relatively lower than that of survivors (8 studies for T3; standardized mean difference (SMD) 1.16; 95% CI, 0.41-1.92; I2 = 97%; P < 0.01). Free thyroxine (FT4) levels in non-survivors were also lower than that of survivors (12 studies; SMD 0.54; 95% CI, 0.31-0.78; I2 = 83%; P < 0.01). There were no statistically significant differences in thyrotropin levels between non-survivors and survivors. NTIS was independently associated with increased risk of mortality in critically ill patients (odds ratio (OR) = 2.21, 95% CI, 1.64-2.97, I2 = 65% P < 0.01). The results favor the concept that decreased thyroid function might be associated with a worse outcome in critically ill patients. Hence, the measurement of TH could provide prognostic information on mortality in adult patients admitted to ICU. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Endocrine connections. Bristol. Vol. 11, no. 2 (2022), e210504, 15 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Critically ill patients | en |
dc.subject | Pacientes incuráveis | pt_BR |
dc.subject | Low T3 levels | en |
dc.subject | Síndromes do eutireóideo doente | pt_BR |
dc.subject | Thyroid hormone | en |
dc.subject | Hormônios tireóideos | pt_BR |
dc.title | Non-thyroidal illness syndrome predicts outcome in adult critically ill patients : a systematic review and meta-analysis | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001168767 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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