Computational biology helps understand how polyploid giant cancer cells drive tumor success
dc.contributor.author | Casotti, Matheus Correia | pt_BR |
dc.contributor.author | Meira, Débora Dummer | pt_BR |
dc.contributor.author | Zetum, Aléxia Stefani Siqueira | pt_BR |
dc.contributor.author | Araújo, Bruno Cancian de | pt_BR |
dc.contributor.author | Silva, Danielle Ribeiro Campos da | pt_BR |
dc.contributor.author | Santos, Eldamária de Vargas Wolfgramm dos | pt_BR |
dc.contributor.author | Rodrigues, Fernanda Mariano Garcia de Souza | pt_BR |
dc.contributor.author | Paula, Flávia de | pt_BR |
dc.contributor.author | Santana, Gabriel Mendonça | pt_BR |
dc.contributor.author | Louro, Luana Santos | pt_BR |
dc.contributor.author | Alves, Lyvia Neves Rebello | pt_BR |
dc.contributor.author | Braga, Raquel Furlani Rocon | pt_BR |
dc.contributor.author | Trabach, Raquel Silva dos Reis | pt_BR |
dc.contributor.author | Bernardes, Sara Santos | pt_BR |
dc.contributor.author | Louro, Thomas Erik Santos | pt_BR |
dc.contributor.author | Chiela, Eduardo Cremonese Filippi | pt_BR |
dc.contributor.author | Lenz, Guido | pt_BR |
dc.contributor.author | Carvalho, Elizeu Fagundes de | pt_BR |
dc.contributor.author | Louro, Iúri Drumond | pt_BR |
dc.date.accessioned | 2023-06-17T03:37:39Z | pt_BR |
dc.date.issued | 2023 | pt_BR |
dc.identifier.issn | 2073-4425 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/259116 | pt_BR |
dc.description.abstract | Precision and organization govern the cell cycle, ensuring normal proliferation. However, some cells may undergo abnormal cell divisions (neosis) or variations of mitotic cycles (endopolyploidy). Consequently, the formation of polyploid giant cancer cells (PGCCs), critical for tumor survival, resistance, and immortalization, can occur. Newly formed cells end up accessing numerous multicellular and unicellular programs that enable metastasis, drug resistance, tumor recurrence, and self-renewal or diverse clone formation. An integrative literature review was carried out, searching articles in several sites, including: PUBMED, NCBI-PMC, and Google Academic, published in English, indexed in referenced databases and without a publication time filter, but prioritizing articles from the last 3 years, to answer the following questions: (i) “What is the current knowledge about polyploidy in tumors?”; (ii) “What are the applications of computational studies for the understanding of cancer polyploidy?”; and (iii) “How do PGCCs contribute to tumorigenesis?” | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Genes. Basel. Vol. 14, no. 4 (Apr. 2023), 801, 20 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Biologia computacional | pt_BR |
dc.subject | Polyploid giant cancer cells (PGCCs) | en |
dc.subject | Bioinformatics | en |
dc.subject | Poliploidia | pt_BR |
dc.subject | Processos patológicos | pt_BR |
dc.subject | Systems biology | en |
dc.subject | Tumor evolution | en |
dc.subject | Neoplasias | pt_BR |
dc.title | Computational biology helps understand how polyploid giant cancer cells drive tumor success | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001168142 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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